CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4085
Family Name Tubulin beta chain Inhibitor Gnf-pf-117 Family
No. of Seeds 2 No. of Other Members 16
Family Centroid CFAMM00302176 Functional Category Investigative Drug with Natural Product
Superfamily Tubulin beta chain and Adenosine receptor A2a Binder Superfamily
Class Class 1608

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Histamine H1 receptor Ligand Tranilast Family 5 125
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Receptor tyrosine-protein kinase erbB-2 Inhibitor Mini-antibod... 1 0
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Tyrosine-protein phosphatase non-receptor type 1 Ligand 2-(oxa... 3 11
Cruzipain Inhibitor 1-(3-methoxy-benzyl)-5-methyl-1h-indole-2,... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Liver carboxylesterase 1 Inhibitor 5-(trifluoromethoxy)-1h-ind... 3 12
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Adenosine receptor A2a Ligand 1-amino-4-methoxyanthracene-9,10... 1 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Amine oxidase [flavin-containing] A and Mitogen-activated prot... 1 71
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Poly [ADP-ribose] polymerase 1 Inhibitor 8-methoxy-2-phenyl-3h... 4 6
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 16
D(2) dopamine receptor Ligand Epidepride Family 31 66
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Protease inhibitor AC1LALME family 2 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 13 20
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Glucocorticoid receptor and Progesterone receptor ligand 1-[4-... 7 4
Ghrelin/growth hormone secretagogue receptor and Cytochrome P4... 5 20
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Progesterone receptor ligand CHEMBL252850 family 2 0
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 2
Muscarinic acetylcholine receptor M1 ligand 5,8-difluoro-1-[(4... 1 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN8058778 family 13 4
Progesterone receptor ligand AGN-PC-080PVV family 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-007ZS... 3 3
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Kinesin-like protein KIF11 inhibitor 3-benzyl-2-(3-hydroxyphen... 2 1
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Adenosine receptor A3 ligand N-(4-methoxyphenyl)-2-oxo-1H-quin... 1 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Cytochrome P450 2D6 inhibitor 2-[(3-butoxyphenoxy)methyl]-3-me... 1 0
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 2 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Amino Acids and Derivatives Metabolite Xanthurenic acid Family 2 0
Benzoxazoles Metabolite 4-Acetyl-2(3H)-benzoxazolone Family 1 0
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
6,8-dimethoxy-4-oxo-1H-quinoline-3-carboxylate NP ZINC00117350... 4 3
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
Putative NP ZINC04043041 Family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302163 DNC014648 Investigative Drug NSC-664171
CFAMM00302176 DNC014634 Investigative Drug GNF-PF-117

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42913 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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