CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4086
Family Name DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimidine-2,4-dione Family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00302186 Functional Category Investigative Drug
Superfamily DNA topoisomerase Binder Superfamily
Class Class 2986

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Urokinase-type plasminogen activator Inhibitor N-(1-adamantyl)... 2 15
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Androgen receptor Ligand YM-175735 Family 30 129
Kinesin-like protein KIF11 Inhibitor N-(4'-bromo-3,3'-difluoro... 2 0
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Voltage-dependent L-type calcium channel subunit alpha-1D Liga... 1 11
Trypsin Inhibitor 1,3-di-p-tolyl-[1,3]diazetidine-2,4-dione Fa... 2 16
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(indan-5-ylamino)-1h-pyrimidine-... 2 0
DNA topoisomerase Inhibitor 6-(3-iodo-phenylamino)-1h-pyrimidi... 2 5
Inosine-5'-monophosphate dehydrogenase inhibitor 1-[2-[3-[(E)-... 3 6
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 6
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
Coagulation factor VII and Prothrombin inhibitor 2-[(4-carbami... 2 1
DNA polymerase III PolC-type inhibitor HB-EMAU family 17 7
DNA polymerase III PolC-type inhibitor SureCN3470957 family 7 0
DNA polymerase III PolC-type inhibitor SureCN3473660 family 2 0
DNA polymerase III PolC-type inhibitor SureCN3471150 family 1 0
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9352718 f... 2 3
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN13328411 ... 4 2
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00F87B f... 3 1
DNA polymerase III PolC-type inhibitor [5-[[3-(4-methoxybutyl)... 2 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302185 CHEMBL2178658 Bioactive 1-naphthalen-2-yl-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea
CFAMM00302186 DNC014638 Investigative Drug 6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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