CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4094
Family Name Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-one Family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00302226 Functional Category Investigative Drug
Superfamily Tubulin beta chain and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 148

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
DNA topoisomerase 2-beta Inhibitor Nalidixic Acid Family 2 5
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Coagulation factor X and Prothrombin inhibitor SureCN7690879 f... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
3-pyrrolidin-1-yl-4,7,8,9-tetrahydrocyclopenta[1,2]pyrido[3,5-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302222 DNC014691 Investigative Drug 2-Naphthalen-2-yl-1H-[1,8]naphthyridin-4-one
CFAMM00302227 DNC014689 Investigative Drug 5-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one
CFAMM00302226 DNC014684 Investigative Drug 2-m-Tolyl-1H-[1,8]naphthyridin-4-one
CFAMM00302224 DNC014678 Investigative Drug 6-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one
CFAMM00302223 DNC014676 Investigative Drug 2-Naphthalen-1-yl-1H-[1,8]naphthyridin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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