CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4097
Family Name Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-methyl-chromen-4-one Family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00302252 Functional Category Investigative Drug with Natural Product
Superfamily Tubulin beta chain and Adenosine receptor A2a Binder Superfamily
Class Class 1608

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Vitamin K epoxide reductase complex subunit 1 Inhibitor Acenoc... 2 46
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Mitogen-activated protein kinase kinase kinase 1 and Mitogen-a... 1 0
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
DNA-dependent protein kinase catalytic subunit Inhibitor 2-(4-... 1 4
Amyloid beta A4 protein Inhibitor 5-hydroxy-2-(4-methylaminoph... 6 71
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Adenosine receptor A2a Ligand 1-amino-4-methoxyanthracene-9,10... 1 7
Adenosine receptor A2a Ligand 1-amino-2-phenoxyanthracene-9,10... 1 4
Aldose reductase Inhibitor 7-hydroxy-6-nitro-2-phenyl-chromen-... 2 17
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 6-brom... 4 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 6-nitr... 5 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 16
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Tyrosinase Inhibitor 4'-amino-4-hydroxychalcone Family 1 4
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
5-hydroxytryptamine receptor 4 ligand AGN-PC-087VMU family 1 4
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 4 65
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Thyroid hormone receptor beta ligand SureCN8800248 family 3 10
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 1 2
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Aldose reductase inhibitor SureCN10487521 family 3 4
Multidrug resistance protein 1 inhibitor UNII-05D072FS97 family 1 3
Retinal dehydrogenase 1 and 3-hydroxyacyl-CoA dehydrogenase ty... 1 3
Major prion protein and Microtubule-associated protein tau inh... 2 10
Thioredoxin glutathione reductase and Muscleblind-like protein... 1 2
Nuclear receptor ROR-gamma and Retinal dehydrogenase 1 ligand ... 1 8
Estrogen receptor beta and Estrogen receptor ligand 8-amino-3-... 2 2
DNA-dependent protein kinase catalytic subunit inhibitor AGN-P... 2 0
methyl 6-amino-4-oxochromene-2-carboxylate NP Methyl 6-amino-4... 1 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
1-benzofuran-3-carboxylate NP ZINC00942066 Family 19 0
Putative NP ZINC11731163 Family 4 2
nitrobenzoate NP 2-[(2e)-3-(2-fluorophenyl)prop-2-enoyl]-4-met... 2 0
Putative NP ZINC09660203 Family 15 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302242 CHEMBL138572 Bioactive AC1LEB0Z
CFAMM00302260 DNC014723 Investigative Drug 2-(4-Amino-phenyl)-6-methyl-chromen-4-one
CFAMM00302252 DNC014712 Investigative Drug 2-(2-Amino-phenyl)-6-methyl-chromen-4-one
CFAMM00302251 DNC014713 Investigative Drug 2-(3-Amino-phenyl)-6-methyl-chromen-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543