CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4099
Family Name Glycine receptor subunit beta Ligand ORG-25543 Family
No. of Seeds 10 No. of Other Members 153
Family Centroid CFAMM00302312 Functional Category Investigative Drug with Natural Product
Superfamily Glycine receptor subunit beta Ligand ORG-25543 Superfamily
Class Class 2998

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Hydrastine family 6 115
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Substance-P receptor Ligand DA-5018 Family 14 73
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Ivabradine family 1 11
Ceramide glucosyltransferase Inhibitor Eliglustat Tartrate Family 3 2
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 3... 1 8
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Neutrophil elastase and Urokinase-type plasminogen activator I... 1 3
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Fatty-acid amide hydrolase 1 Inhibitor 4-(cyclohexylmethylcarb... 2 4
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Acetylcholinesterase Inhibitor Taspine Family 1 0
DNA topoisomerase 1 Inhibitor NSC-341622 Family 1 1
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
D(2) dopamine receptor Ligand (s)-secoantioquine Family 1 10
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Pyruvate kinase PKM and Pyruvate kinase PKLR inhibitor MLS0022... 1 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Prothrombin inhibitor N-cyclohexyl-3-[3-(diaminomethylideneami... 3 4
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Transient receptor potential cation channel subfamily V member... 3 18
Prothrombin inhibitor (2S)-N-[(4-aminocyclohexyl)methyl]-1-[2-... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Rho-associated protein kinase 1 and Rho-associated protein kin... 1 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Histamine H1 receptor ligand Ahr 5333 family 1 6
Sodium/hydrogen exchanger 1 inhibitor AGN-PC-072XB4 family 2 2
Sodium/hydrogen exchanger 1 inhibitor AGN-PC-0A9S6A family 1 3
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X1U ... 2 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2-... 4 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Acetylcholinesterase inhibitor (5S)-5-[4-(5,6-dimethoxy-3-oxo-... 1 3
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Pol polyprotein inhibitor AC1LA3AI family 5 9
Cathepsin D and Plasmepsin-2 inhibitor 1-acetyl-N-[2-(1,3-benz... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Cholinesterase and Acetylcholinesterase inhibitor 3,4,5-trimet... 1 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 2 20
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07R5XZ family 2 2
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Cytochrome P450 3A4 inhibitor N-[(2S,3S)-2-(1,3-benzodioxol-5-... 4 5
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Capsid scaffolding protein inhibitor AC1LAC52 family 1 0
Histamine H1 receptor ligand SureCN7952197 family 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-00... 5 14
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 2 1
Enoyl-[acyl-carrier-protein] reductase [NADPH] inhibitor 4-(4-... 1 1
Nuclear receptor ROR-gamma ligand 3-(1,3-benzodioxol-5-yl)-1-(... 3 36
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 1 5
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
Renin inhibitor (4S,5S,7S)-5-amino-N-butyl-7-[[4-tert-butyl-3-... 2 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 20
Glutamate carboxypeptidase 2 inhibitor 2-(4-hydroxy-3-methoxyp... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 1
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 4 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Adenosine receptor A2a and Adenosine receptor A2b ligand N-(2-... 3 0
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Lysophosphatidic acid receptor 3 ligand [4-[(2R)-2-[[(Z)-octad... 1 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor meth... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
Stilbenes Metabolite Narceine Family 1 7
Stilbenes Metabolite (Z)-Narceine imide Family 1 1
Putative NP ZINC31164438 Family 18 0
Putative NP ZINC20113153 Family 20 0
NP (e)-4-methoxy-6,6-dimethyl-5-(2-oxo-4-(2,6,6-trimethylcyclo... 131 0
Putative NP ZINC02127056 Family 4 1
NP (z)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-1(2h)-ylidene)-... 3 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
6,7-dihydropyrimido[6,1-a]isoquinolin-4-one NP ZINC02112138 Fa... 10 0
(1R,5S)-3-(2-(3,4,5-trimethoxyphenyl)acetyl)-3,4,5,6-tetrahydr... 2 0
Putative NP ZINC08791780 Family 3 0
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 2
Putative NP ZINC02099241 Family 12 0
Putative NP ZINC00519603 Family 8 1
Putative NP ZINC02134473 Family 4 0
4-[[(1R,9aR)-1,2,3,4,5,6,7,8,9,9a-decahydroquinolizin-5-ium-1-... 1 0
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0
3-(3,4-dimethoxyphenyl)-3-[3-(7-methoxy-4,8-dimethyl-2-oxochro... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302332 CHEMBL2013230 Bioactive N-[(E)-3-(2-fluorophenyl)-2-methylprop-2-enyl]-3,4,5-trimethoxy-N-[2-(1-methylpyrrolidin-2-yl)ethyl]benzamide
CFAMM00302311 CHEMBL1200887 Bioactive Trimethobenzamide hydrochloride
CFAMM00302398 CHEMBL97259 Bioactive AC1O5XZK
CFAMM00302346 CHEMBL188937 Bioactive AGN-PC-075HHH
CFAMM00302504 CHEMBL32684 Bioactive N-[(2S,3S)-3-[(3,5-dimethoxy-4-phenylmethoxybenzoyl)amino]-2-hydroxy-4-phenylbutyl]-N-[2-(4-methoxyphenyl)ethyl]-1-methylpiperidine-4-carboxamide
CFAMM00302279 CHEMBL472905 Bioactive (2S,4S)-1-acetyl-N-hydroxy-4-[(3,4,5-trimethoxybenzoyl)amino]pyrrolidine-2-carboxamide
CFAMM00302278 CHEMBL557063 Bioactive N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-4-methoxy-3-(3-methoxypropoxy)-N-propan-2-ylbenzamide
CFAMM00302351 CHEMBL284955 Bioactive N-[(2S,3S)-3-[(3,5-dimethoxy-4-phenylmethoxybenzoyl)amino]-2-hydroxy-4-phenylbutyl]-N-[2-(4-methoxyphenyl)ethyl]piperidine-4-carboxamide
CFAMM00302312 DNC014722 Investigative Drug ORG-25543

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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