CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4106
Family Name Liver carboxylesterase 1 Inhibitor SM-32504 Family
No. of Seeds 3 No. of Other Members 28
Family Centroid CFAMM00302580 Functional Category Investigative Drug with Natural Product
Superfamily Chymase and Liver carboxylesterase 1 Binder Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Family 1 4
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Glycogen synthase kinase-3 beta inhibitor AGN-PC-0802SH family 1 2
Glycogen synthase kinase-3 beta inhibitor 6-[(2S)-2-(2-methoxy... 1 0
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-(2-hy... 24 0
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Melanin-concentrating hormone receptor 1 ligand 1-[6-[(3R)-3-a... 1 5
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4... 13 1
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Melanocortin receptor 4 ligand N-[(2R)-3-(2,4-dichlorophenyl)-... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 5
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Sterol O-acyltransferase 1 inhibitor AGN-PC-07CO2O family 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Glycogen synthase kinase-3 beta and G1/S-specific cyclin-E2 in... 2 0
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302587 CHEMBL541893 Bioactive AGN-PC-07C2P2
CFAMM00302598 CHEMBL557982 Bioactive AGN-PC-07C13D
CFAMM00302580 DNC014762 Investigative Drug SM-32504

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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