CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4116
Family Name Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic Acid Family
No. of Seeds 2 No. of Other Members 66
Family Centroid CFAMM00302739 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Glucocorticoid receptor Ligand GW685698X Superfamily
Class Class 987

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5... 1 9
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Kappa-type opioid receptor Ligand Salvinorin B Butoxymethyl Et... 38 215
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Fatty-acid amide hydrolase 1 Inhibitor Benzofuran-2-ylboronic ... 1 14
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 11
Thromboxane A2 receptor and Prostacyclin receptor ligand AGN-P... 2 30
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Tyrosine-protein phosphatase non-receptor type 1 ligand (2S)-2... 9 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 5 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Tyrosine-protein phosphatase non-receptor type 1 ligand 4-[4-[... 6 2
Estrogen receptor beta and Mitogen-activated protein kinase 1 ... 1 2
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 3 2
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Methionine aminopeptidase and Nonstructural protein 1 inhibito... 3 1
Methionine aminopeptidase inhibitor 5-[2-(Trifluoromethoxy)phe... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 1
Putative Bioactive AC1O5G5E Family 1 1
Methionine aminopeptidase inhibitor AGN-PC-075YEQ family 1 0
Glycogen synthase kinase-3 beta inhibitor IRCININ 1 family 1 0
Histone deacetylase 6 and Histone deacetylase 4 inhibitor ETHY... 1 6
Furans Metabolite 2-Furoic acid Family 2 9
Carbonyl Compounds Metabolite 1-(5-Methyl-2-furanyl)-1,2-propa... 2 4
Furans Metabolite Isoamyl 2-furoate Family 4 6
Furans Metabolite Perilla ketone Family 2 5
Furans Metabolite 5-Hydroxymethyl-2-furancarboxaldehyde Family 2 8
Furans Metabolite 2-Acetyl-3-methylfuran Family 1 3
Carboxylic Acids and Derivatives Metabolite Mumefural Family 1 0
Prenol Lipids Metabolite Furanogermenone Family 2 2
Sphydrofuran Derivative NP ZINC14591771 Family 4 1
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
1,3-dimethylcyclohepta[c]furan-8-one NP 8-hydroxy-6-(4-methoxy... 10 0
6-(furan-2-yl)-2,4,9-trimethyl-7-oxabicyclo[3.3.1]non-3-ene NP... 6 0
Putative NP ZINC00139814 Family 6 0
NP Agn-pc-05wmi6 Family 2 0
NP 4-(7-methoxybenzofuran-2-yl)-2-oxo-7-phenyl-2h-chromen-6-yl... 9 0
5-[2-[2-[(4-chlorobenzoyl)oxymethyl]furan-3-yl]ethyl]-1,4a-dim... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302691 CHEMBL247529 Bioactive AGN-PC-02W5KT
CFAMM00302739 DNC014785 Investigative Drug 5-(4'-benzoylbiphenyl-4-yl)-2-furoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48713 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543