CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID414
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15943 Family
No. of Seeds 24 No. of Other Members 47
Family Centroid CFAMM00190762 Functional Category Investigative Drug
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15943 Superfamily
Class Class 1587

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand ZM-241... 2 5
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 0
Histamine H4 receptor and Histamine H3 receptor ligand SureCN6... 17 51
Adenosine receptor A2a ligand SureCN6867940 family 13 13
5-hydroxytryptamine receptor 6 ligand F1609-0206 family 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 8 0
Prelamin-A/C and Prothrombin inhibitor (3-Furan-2-yl-5-methyls... 2 1
Adenosine receptor A3 and Adenosine receptor A2b ligand CHEMBL... 5 0
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2a ligand 5-N-[[(2R)-1-[(2-chloro-3,6-difl... 7 9
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Adenosine receptor A2a ligand 7-(3,4-dimethoxyphenyl)-2-(furan... 6 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Adenosine receptor A2a ligand 5-[(7S,9aS)-7-[(2-fluorophenoxy)... 5 4
P2X purinoceptor 7 inhibitor SureCN110566 family 1 0
Cannabinoid receptor 2 ligand N-cyclohexyl-2-(furan-2-yl)-7-ox... 3 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
5-hydroxytryptamine receptor 3A and Histamine H4 receptor liga... 1 0
Adenosine receptor A2a ligand SureCN8368237 family 1 0
Adenosine receptor A2a ligand AGN-PC-02Z2S3 family 3 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand triazi... 3 0
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 0
Nuclear receptor ROR-gamma and Hypoxia-inducible factor 1-alph... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00190725 CHEMBL97484 Bioactive methyl 8-[[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]amino]-8-oxooctanoate
CFAMM00190716 CHEMBL414023 Bioactive 104615-00-1
CFAMM00190732 CHEMBL329284 Bioactive N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-(3-chlorophenyl)acetamide
CFAMM00190692 CHEMBL97307 Bioactive N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-(3-iodophenyl)acetamide
CFAMM00190731 CHEMBL411692 Bioactive (2R)-N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylpropanamide
CFAMM00190737 CHEMBL319539 Bioactive tert-butyl N-[3-[[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]amino]-3-oxopropyl]carbamate
CFAMM00190744 CHEMBL317580 Bioactive N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2,2-diphenylacetamide
CFAMM00190759 CHEMBL98570 Bioactive tert-butyl N-[5-[[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]amino]-5-oxopentyl]carbamate
CFAMM00190758 CHEMBL97753 Bioactive 5-[[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]amino]-5-oxopentanoic acid
CFAMM00190711 CHEMBL174850 Bioactive SureCN6047334
CFAMM00190742 CHEMBL95820 Bioactive N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-(4-iodophenyl)acetamide
CFAMM00190757 CHEMBL329722 Bioactive SureCN1663612
CFAMM00190718 CHEMBL2114300 Bioactive tert-butyl N-[1-[[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]amino]-1-oxopropan-2-yl]carbamate;methanol
CFAMM00190734 CHEMBL98464 Bioactive (2S)-N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylpropanamide
CFAMM00190755 CHEMBL141550 Bioactive 1-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-3-(3-chlorophenyl)urea
CFAMM00190733 CHEMBL97748 Bioactive 2-(4-aminophenyl)-N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]acetamide
CFAMM00190748 CHEMBL317382 Bioactive N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)benzamide
CFAMM00190762 DNC003540 Investigative Drug CGS-15943
CFAMM00190709 DNC000961 Investigative Drug MRS-1220

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45127 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543