CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4169
Family Name Protein kinase C alpha type Inhibitor Dequalinium Analogue Family
No. of Seeds 1 No. of Other Members 10
Family Centroid CFAMM00303577 Functional Category Investigative Drug
Superfamily Protein kinase C alpha type and Protein kinase C theta type Binder Superfamily
Class Class 1116

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
HIV protease Inhibitor Saquinavir Family 64 428
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Amg 423 family 7 47
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Histamine H4 receptor Ligand A-943931 Family 14 11
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Urotensin-2 receptor Ligand Palosuran Family 4 4
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Hepatocyte growth factor receptor ligand AGN-PC-09M1N4 family 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 4
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Motilin receptor ligand SureCN2768052 family 3 0
Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... 2 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Capsid scaffolding protein inhibitor AC1O583J family 5 1
Androgen receptor ligand SureCN7034488 family 1 13
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Transient receptor potential cation channel subfamily V member... 1 0
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0
Hexokinase and Farnesyl pyrophosphate synthase inhibitor AC1NQ... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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