CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4198
Family Name Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00304030 Functional Category Investigative Drug
Superfamily Cholinesterase and Acetylcholinesterase Binder Superfamily 3
Class Class 825

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (2Z)-... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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