CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4214
Family Name Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta Ligand WAY-254011 Family
No. of Seeds 22 No. of Other Members 57
Family Centroid CFAMM00304165 Functional Category Bioactive with Natural Product
Superfamily Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta Ligand WAY-254011 Superfamily
Class Class 3035

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
PF-02545920 family 16 140
Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103... 14 12
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Renin Inhibitor CP-305202 Family 9 30
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
B2 bradykinin receptor ligand SureCN8516699 family 3 2
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 5
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Somatostatin receptor type 2 ligand SureCN4325675 family 3 1
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Peroxisome proliferator-activated receptor delta and Peroxisom... 22 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 7 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 5 1
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Thromboxane-A synthase inhibitor (E)-7-[4-[5-[(2S,4S,5R)-5-[(Z... 3 9
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Thromboxane-A synthase inhibitor SureCN9045578 family 1 12
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Proteinase-activated receptor 1 ligand ethyl N-[(1R,3aR,4aR,6R... 1 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Bile acid receptor ligand pyridin-4-yl (1R,3aS,5aR,5bR,7aR,9S,... 1 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 14 2
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Free fatty acid receptor 1 ligand AGN-PC-0A9RM5 family 1 0
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
Arachidonate 5-lipoxygenase inhibitor 4-(furan-3-yl)-7-[[5-(4-... 2 1
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Cytosolic phospholipase A2 inhibitor SureCN3681683 family 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
7-(4-hydroxy-2-oxo-2H-chromen-3-yl)chromeno[4',3':3,4]cyclopen... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00304205 CHEMBL220570 Bioactive SureCN1400566
CFAMM00304158 CHEMBL254542 Bioactive 2-[4-[[3-[3-benzoyl-8-(trifluoromethyl)quinolin-5-yl]phenoxy]methyl]phenyl]-2-prop-2-ynylpent-4-ynoic acid
CFAMM00304220 CHEMBL254333 Bioactive 2-[4-[[3-[3-benzoyl-8-(trifluoromethyl)quinolin-5-yl]phenoxy]methyl]phenyl]acetic acid
CFAMM00304164 CHEMBL502579 Bioactive SureCN1125762
CFAMM00304171 CHEMBL214719 Bioactive Quinoline 15
CFAMM00304197 CHEMBL595118 Bioactive SureCN1125264
CFAMM00304163 CHEMBL386772 Bioactive Quinoline 14
CFAMM00304190 CHEMBL595124 Bioactive AGN-PC-014WOZ
CFAMM00304203 CHEMBL593960 Bioactive SureCN1125561
CFAMM00304156 CHEMBL450409 Bioactive SureCN1126046
CFAMM00304176 CHEMBL1223687 Bioactive AGN-PC-080AQM
CFAMM00304216 CHEMBL404468 Bioactive AGN-PC-04XTB9
CFAMM00304155 CHEMBL505445 Bioactive SureCN1125860
CFAMM00304161 CHEMBL454596 Bioactive SureCN1125992
CFAMM00304175 CHEMBL254945 Bioactive AGN-PC-04XSAI
CFAMM00304188 CHEMBL403958 Bioactive 2-[4-[[3-[3-benzoyl-8-(trifluoromethyl)quinolin-5-yl]phenoxy]methyl]phenyl]pent-4-enoic acid
CFAMM00304223 CHEMBL254539 Bioactive 2-[4-[[3-[3-benzoyl-8-(trifluoromethyl)quinolin-5-yl]phenoxy]methyl]phenyl]hex-4-ynoic acid
CFAMM00304159 CHEMBL254541 Bioactive 2-[4-[[3-[3-benzoyl-8-(trifluoromethyl)quinolin-5-yl]phenoxy]methyl]phenyl]hept-4-ynoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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