CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4223
Family Name Potassium voltage-gated channel subfamily H member 2 Ligand (1r,5r)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18.6.2.1^{2,5}.1^{14,18}.0^{8, 12}.0^{23,27}]triaconta-8,10,14(29),15,17,20(28),21,23(27)-octaene-17-carbonitri Le (structural Mix) Family
No. of Seeds 64 No. of Other Members 70
Family Centroid CFAMM00304368 Functional Category Investigative Drug
Superfamily Potassium voltage-gated channel subfamily H member 2 Ligand (1r,5r)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18.6.2.1^{2,5}.1^{14,18}.0^{8, 12}.0^{23,27}]triaconta-8,10,14(29),15,17,20(28),21,23(27)-octaene-17-carbonitri Le (structural Mix) Superfamily
Class Class 1096

Cousin Family NamesSeedsMembers
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
SB1518 family 7 103
Eluxadoline family 4 85
Renin Inhibitor Enalkiren Family 56 44
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Aromatase Inhibitor 3-((1h-imidazol-1-yl)methyl)-9h-xanthen-9-... 6 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 1-... 2 9
Aromatase Inhibitor 4-((1h-imidazol-1-yl)methyl)-2h-chromen-2-... 3 69
Cytochrome P450 3A4 Inhibitor SK&F-96365 Family 2 26
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Rac-4'-(1-i... 5 9
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 14 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Extracellular calcium-sensing receptor ligand SureCN2972008 fa... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 19 2
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 8 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Pol polyprotein inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-... 7 3
Cytochrome P450 26A1 and Cytochrome P450 3A4 inhibitor 3-[6-[(... 14 26
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
Sodium- and chloride-dependent glycine transporter 1 and Potas... 14 3
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00304329 CHEMBL523080 Bioactive CHEMBL523080
CFAMM00304343 CHEMBL526656 Bioactive CHEMBL526656
CFAMM00304403 CHEMBL52610 Bioactive CHEMBL52610
CFAMM00304416 CHEMBL346589 Bioactive AGN-PC-01XLNP
CFAMM00304370 CHEMBL50857 Bioactive AGN-PC-073SCF
CFAMM00304383 CHEMBL53821 Bioactive CHEMBL53821
CFAMM00304396 CHEMBL498100 Bioactive CHEMBL498100
CFAMM00304336 CHEMBL300206 Bioactive AGN-PC-01WKN5
CFAMM00304409 CHEMBL55826 Bioactive 1ld7
CFAMM00304389 CHEMBL312034 Bioactive AGN-PC-00F06Q
CFAMM00304328 CHEMBL347018 Bioactive CHEMBL347018
CFAMM00304415 CHEMBL54212 Bioactive SureCN7635537
CFAMM00304369 CHEMBL516874 Bioactive CHEMBL516874
CFAMM00304428 CHEMBL310943 Bioactive AGN-PC-01VXYF
CFAMM00304408 CHEMBL53154 Bioactive CHEMBL53154
CFAMM00304421 CHEMBL283369 Bioactive CHEMBL283369
CFAMM00304335 CHEMBL312121 Bioactive AGN-PC-03WQBG
CFAMM00304375 CHEMBL349329 Bioactive AGN-PC-02WAKV
CFAMM00304448 CHEMBL156225 Bioactive AGN-PC-02WAJW
CFAMM00304341 CHEMBL526521 Bioactive CHEMBL526521
CFAMM00304414 CHEMBL298895 Bioactive SureCN7626894
CFAMM00304381 CHEMBL52921 Bioactive SureCN7629099
CFAMM00304347 CHEMBL465417 Bioactive CHEMBL465417
CFAMM00304360 CHEMBL77504 Bioactive AGN-PC-00F1NW
CFAMM00304420 CHEMBL496879 Bioactive (20s)-19,20,21,22-tetrahydro-19-oxo-5h-18,20-ethano-12,14-etheno-6,10-metheno-18h-benz[d]imidazo[4,3-k][1,6,9,12]oxatriaza-cyclooctadecosine-9-carbonitrile
CFAMM00304374 CHEMBL423303 Bioactive CHEMBL423303
CFAMM00304413 CHEMBL329932 Bioactive AGN-PC-00EZMT
CFAMM00304353 CHEMBL52073 Bioactive SureCN3516578
CFAMM00304366 CHEMBL312459 Bioactive AGN-PC-074KBY
CFAMM00304346 CHEMBL526466 Bioactive CHEMBL526466
CFAMM00304359 CHEMBL23155 Bioactive SureCN7159206
CFAMM00304446 CHEMBL78742 Bioactive AGN-PC-074KH7
CFAMM00304425 CHEMBL53037 Bioactive AGN-PC-073SHB
CFAMM00304379 CHEMBL423062 Bioactive AGN-PC-02WAKW
CFAMM00304439 CHEMBL53862 Bioactive SureCN7633566
CFAMM00304392 CHEMBL524082 Bioactive CHEMBL524082
CFAMM00304405 CHEMBL348336 Bioactive SureCN1434347
CFAMM00304345 CHEMBL525369 Bioactive (1R,5R)-30-OXO-19-OXA-2,6,10,12-TETRAAZAHEXACYCLO[18.6.2.1^{2,5}.1^{14,18}.0^{8,12}.0^{23,27}]TRIACONTA-8,10,14(29),15,17,20(28),21,23(27)-OCTAENE-17-CARBONITRILE (STRUCTURAL MIX)
CFAMM00304418 CHEMBL52975 Bioactive CHEMBL52975
CFAMM00304372 CHEMBL502560 Bioactive CHEMBL502560
CFAMM00304411 CHEMBL442552 Bioactive CHEMBL442552
CFAMM00304378 CHEMBL80702 Bioactive AC1L1B3H
CFAMM00304330 CHEMBL53811 Bioactive AGN-PC-073SCO
CFAMM00304357 CHEMBL54969 Bioactive SureCN7628449
CFAMM00304371 CHEMBL280181 Bioactive AGN-PC-076HU8
CFAMM00304417 CHEMBL361246 Bioactive AGN-PC-014VYQ
CFAMM00304344 CHEMBL525368 Bioactive CHEMBL525368
CFAMM00304397 CHEMBL52859 Bioactive CHEMBL52859
CFAMM00304337 CHEMBL23650 Bioactive AGN-PC-076HS2
CFAMM00304350 CHEMBL311561 Bioactive AGN-PC-046PDB
CFAMM00304377 CHEMBL301491 Bioactive AGN-PC-01WKMJ
CFAMM00304436 CHEMBL299568 Bioactive CHEMBL299568
CFAMM00304450 CHEMBL310586 Bioactive AGN-PC-046QM7

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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