CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4229
Family Name Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-tert-butylphenylthio)ethyl)-1h-imidazole Family
No. of Seeds 25 No. of Other Members 10
Family Centroid CFAMM00304677 Functional Category Investigative Drug
Superfamily Alpha-2 adrenergic receptor Ligand Dexmedetomidine Superfamily
Class Class 177

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Telomerase protein component 1 Inhibitor GRN163L Family 5 29
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Tryptase Inhibitor Babim Family 12 90
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Histamine H3 receptor Ligand Proxyfan Family 12 32
Histamine H3 receptor Ligand SCH79687 Family 11 29
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 6 6
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Histamine H3 receptor Ligand GT-2016 Family 4 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Motilin receptor and Growth hormone secretagogue receptor type... 2 2
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Histamine H3 receptor ligand SureCN7853275 family 2 5
Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... 8 90
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Alpha-1D adrenergic receptor ligand 5-[(3-bromothiophen-2-yl)m... 8 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 2 2
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Alpha-1D adrenergic receptor ligand (E)-but-2-enedioic acid;5-... 8 1
Alpha-1D adrenergic receptor ligand (E)-but-2-enedioic acid;5-... 1 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
S-methyl-5'-thioadenosine phosphorylase inhibitor 2-[[(4-amino... 5 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Dipeptidyl peptidase 4 and Seprase inhibitor (1S,5S)-5-[3-(tri... 1 0
Methionine aminopeptidase 2 inhibitor SureCN5373581 family 6 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Histamine H3 receptor ligand AGN-PC-074FK2 family 4 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
5-hydroxytryptamine receptor 2B ligand SureCN1299213 family 3 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(3,4-dichlor... 2 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Histamine H4 receptor and Histamine H3 receptor ligand AGN-PC-... 1 2
Histamine H3 receptor and Histamine H4 receptor ligand AGN-PC-... 1 2
Sodium/hydrogen exchanger 1 inhibitor SureCN14276439 family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Histamine H3 receptor ligand AGN-PC-074FFM family 1 2
Histamine H3 receptor ligand 5-(3-bromophenyl)-2-[2-(1H-imidaz... 2 2
Cytochrome P450 11B1, mitochondrial and Aromatase inhibitor (1... 1 0
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 3 2
Glucocorticoid receptor ligand SureCN13513652 family 1 0
Alpha-1A adrenergic receptor ligand 2-[4-(methylsulfonylmethyl... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00304685 CHEMBL68718 Bioactive AGN-PC-074FFO
CFAMM00304691 CHEMBL1744276 Bioactive (E)-but-2-enedioic acid;5-[(2,5-diethylthiophen-3-yl)methyl]-1H-imidazole
CFAMM00304669 CHEMBL367117 Bioactive AGN-PC-0759OW
CFAMM00304684 CHEMBL1744270 Bioactive 5-(1-benzothiophen-3-ylmethyl)-1H-imidazole;(E)-but-2-enedioic acid
CFAMM00304690 CHEMBL1744277 Bioactive (E)-but-2-enedioic acid;5-[(2,5-dimethylthiophen-3-yl)methyl]-1H-imidazole
CFAMM00304675 CHEMBL1237160 Bioactive 5-[1-(3-methylthiophen-2-yl)ethyl]-1H-imidazole;hydrochloride
CFAMM00304668 CHEMBL1744269 Bioactive (E)-but-2-enedioic acid;5-[1-(2-methylthiophen-3-yl)ethyl]-1H-imidazole
CFAMM00304683 CHEMBL1203856 Bioactive 5-(4,5,6,7-tetrahydro-1-benzothiophen-2-ylmethyl)-1H-imidazole;hydrochloride
CFAMM00304689 CHEMBL1744272 Bioactive (E)-but-2-enedioic acid;5-[(2,4-dimethylthiophen-3-yl)methyl]-1H-imidazole
CFAMM00304667 CHEMBL1744267 Bioactive (E)-but-2-enedioic acid;5-[1-(3-methylthiophen-2-yl)propyl]-1H-imidazole
CFAMM00304682 CHEMBL1203851 Bioactive 5-(1-benzothiophen-2-ylmethyl)-1H-imidazole;hydrochloride
CFAMM00304688 CHEMBL1744294 Bioactive (E)-but-2-enedioic acid;5-[(2-methylthiophen-3-yl)methyl]-1H-imidazole
CFAMM00304681 CHEMBL1203848 Bioactive 5-[(3-methylthiophen-2-yl)methyl]-1H-imidazole;hydrochloride
CFAMM00304672 CHEMBL170960 Bioactive 5-[1-(3-methylthiophen-2-yl)ethyl]-1H-imidazole
CFAMM00304693 CHEMBL1744281 Bioactive (E)-but-2-enedioic acid;5-[1-(3,4-dimethylthiophen-2-yl)ethyl]-1H-imidazole
CFAMM00304664 CHEMBL1203846 Bioactive 5-[(3,4-dimethylthiophen-2-yl)methyl]-1H-imidazole;hydrochloride
CFAMM00304678 CHEMBL1098002 Bioactive AGN-PC-07ZEVA
CFAMM00304692 CHEMBL1744288 Bioactive (E)-but-2-enedioic acid;5-[(2-ethylthiophen-3-yl)methyl]-1H-imidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27397 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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