CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID423
Family Name M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs Family
No. of Seeds 11 No. of Other Members 56
Family Centroid CFAMM00190986 Functional Category Investigative Drug with Natural Product
Superfamily Zucapsacin Superfamily
Class Class 725

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Vernakalant family 1 1
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Tubulin beta chain Inhibitor Colchinol Family 3 109
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Amine oxidase [flavin-containing] A Inhibitor 2-(4-methoxyphen... 2 7
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 3 5
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 2
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Transient receptor potential cation channel subfamily V member... 3 18
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
Transient receptor potential cation channel subfamily V member... 14 7
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Cholinesterase and Acetylcholinesterase inhibitor AGN-PC-009M2... 1 6
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 3
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 11 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 10 8
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
High affinity choline transporter 1 inhibitor 1-[4-(3,4,5-trim... 2 3
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor Sure... 4 4
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0A9S9E... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand N-(2-... 3 0
Endothelin-converting enzyme 1 inhibitor [[(2S)-5-(2,4-difluor... 1 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor meth... 1 1
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
Putative NP ZINC14589285 Family 2 1
Putative NP ZINC04029215 Family 6 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC04029538 Family 3 0
Putative NP ZINC19322380 Family 2 2
Putative NP ZINC13119705 Family 3 0
NP (1s,5r,z)-2-(1-((4-methoxybenzyl)amino)ethylidene)-6,6-dime... 4 0
Putative NP ZINC02099241 Family 12 0
Putative NP ZINC04287792 Family 2 0
2-(2,3,4,8,9,10-hexahydro-[1,4]dioxepino[2,3-g]isoquinolin-7-y... 4 0
Putative NP ZINC01322649 Family 2 0
Putative NP ZINC00050501 Family 6 4
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00191013 CHEMBL127899 Bioactive 1-[4-methoxy-3-(2-phenylethoxy)phenyl]-N-propylbutan-2-amine
CFAMM00190956 CHEMBL545760 Bioactive 1-[4-methoxy-3-(2-phenylethoxy)phenyl]-N-propylpropan-2-amine;hydrochloride
CFAMM00190973 CHEMBL318836 Bioactive AGN-PC-074TAZ
CFAMM00191003 CHEMBL128799 Bioactive 1-[4-methoxy-3-(2-phenylethoxy)phenyl]-N-propylpentan-2-amine
CFAMM00191018 CHEMBL128860 Bioactive 1-[4-methoxy-3-(2-phenylethoxy)phenyl]-N-propylhexan-2-amine
CFAMM00190971 CHEMBL2112409 Bioactive CHEMBL2112409
CFAMM00190970 CHEMBL2112408 Bioactive 5-[3-[[(3R)-3-bicyclo[2.2.1]heptanyl]oxy]-4-methoxyphenyl]-1-methylimidazolidin-2-one
CFAMM00190976 CHEMBL2111611 Bioactive 5-[3-[[(3S)-3-bicyclo[2.2.1]heptanyl]oxy]-4-methoxyphenyl]-1-methylimidazolidin-2-one
CFAMM00191006 CHEMBL339638 Bioactive 1-[4-methoxy-3-(2-phenylethoxy)phenyl]-N-propyloctan-2-amine
CFAMM00191014 CHEMBL553962 Bioactive AGN-PC-07C01J
CFAMM00190986 DNC000990 Investigative Drug Naphthoquinone analogs

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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