CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4232
Family Name Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-n-(hydroxymethyl)-1,2,2-trimethyl-1,2, 3,4-tetrahydro-1,8-naphthyridine-4-carboxamide (enantiomeric Mix) Family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00304763 Functional Category Investigative Drug
Superfamily Cannabinoid receptor 2 and Cannabinoid receptor 1 Binder Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand Napht... 5 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 5 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 10
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 1 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 7 1
Integrin alpha-V and Integrin beta-6 inhibitor SureCN12259087 ... 3 4
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 6-(2-... 2 0
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00304767 CHEMBL1082650 Bioactive 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-((R)-1-HYDROXYETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX)
CFAMM00304765 CHEMBL393584 Bioactive N-[(1R)-1-[2-[4-[(2R)-3-(2,4-dichlorophenyl)-2-methylpropanoyl]piperazin-1-yl]-6-methylpyridin-3-yl]-3-methylbutyl]-3-(dimethylamino)propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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