CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID4249
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Ligand 1-methyl-1,3-dihydro-indol-2-one Family
No. of Seeds 53 No. of Other Members 289
Family Centroid CFAMM00305311 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Ligand 1-methyl-1,3-dihydro-indol-2-one Superfamily
Class Class 3044

Cousin Family NamesSeedsMembers
Benzodiazepine receptor ligand benzodiazepine derivative Fludi... 11 78
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Benzodiazepine receptor ligand benzodiazepine derivative Oxaze... 4 0
Benzodiazepine receptor Ligand Clorazepate Family 2 3
Mu-type opioid receptor ligand opiate Remifentanil Family 10 24
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Benzodiazepine receptor ligand benzodiazepine derivative Fluni... 2 22
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Nitric oxide synthase, brain Inhibitor NXN-188 Family 1 7
Motilin receptor Ligand GSK962040 Family 30 457
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
HT-2157 family 1 3
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 4 Ligand TD-5108 Family 21 24
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 4-methyl-5,6... 3 12
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Cruzipain Inhibitor 5-chloro-1-(4-chloro-benzyl)-1h-indole-2,3... 3 13
Androgen receptor Ligand LG-121071 Family 8 32
Integrin beta-3 Inhibitor L-750034 Family 7 38
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Fatty acid-binding protein and C-X-C chemokine receptor type 1... 1 6
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Aurora kinase B Inhibitor Hesperadin Family 1 1
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
M-phase inducer phosphatase 1 Inhibitor (z)-2-(1-decyl-2-oxoin... 2 2
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Neutrophil elastase Inhibitor 3-butyl-3-ethyl-1-phenylazetidin... 6 5
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Cruzipain Inhibitor N1,n4-bis(5-chloro-2-methylphenyl)succinam... 1 5
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand CH... 3 5
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 4 18
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 2
Sigma non-opioid intracellular receptor 1 and Histamine H1 rec... 5 9
5-hydroxytryptamine receptor 6 ligand 1-(5-chloronaphthalen-1-... 1 5
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Neuropeptide S receptor ligand AGN-PC-071SSH family 1 6
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 0
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Coagulation factor X inhibitor AGN-PC-00QIZ9 family 2 15
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Neuropeptide Y receptor type 2 ligand N-[3-chloro-4-[2-(cyclop... 1 2
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Androgen receptor and Progesterone receptor ligand (5bR,9aR)-1... 1 0
Equilibrative nucleoside transporter 1 inhibitor Draflazine fa... 1 8
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Androgen receptor ligand CHEMBL178886 family 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Neuropeptide Y receptor type 5 ligand 2-(6-chloro-3,4-dihydro-... 5 1
Melanin-concentrating hormone receptor 1 ligand 4-(4-chlorophe... 2 0
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-[... 18 26
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 2 1
Histamine H3 receptor ligand SureCN3058680 family 4 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-044QVW fa... 10 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-00CHN2 f... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
C-C chemokine receptor type 5 ligand AC1MHYGF family 3 2
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(2-... 1 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GBV family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Translocator protein inhibitor CHEMBL2332254 family 6 1
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor ligand AGN-PC-0CW63F family 1 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Histamine receptor H3 ligand N-[4-[3-(2-methylpyrrolidin-1-yl)... 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(2R,3R)-3-(4-c... 1 0
Kappa-type opioid receptor ligand AGN-PC-077Q4Y family 5 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 6,7-dichlo... 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Chitin synthase 1 inhibitor AGN-PC-073JUR family 2 1
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Mu-type opioid receptor ligand AGN-PC-00NCMY family 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Progesterone receptor ligand CHEMBL403139 family 2 0
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 3 1
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Melanocortin receptor 4 ligand 2-amino-N-[(2R)-3-(2,4-dichloro... 5 5
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
C-C chemokine receptor type 1 ligand (2R)-2-N-[(4-chlorophenyl... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Transient receptor potential cation channel subfamily V member... 1 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Dipeptidyl peptidase 4 inhibitor (2S,4S)-1-[2-[[1-[4-cyano-2-(... 2 0
Calcitonin gene-related peptide type 1 receptor and Dual speci... 4 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Vascular endothelial growth factor receptor 2 ligand SureCN578... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Progesterone receptor ligand SureCN3031001 family 8 40
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 3
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Integrin alpha-L inhibitor SureCN6314317 family 2 1
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 7 1
Neuropeptide Y receptor type 2 ligand JNJ-5207787 family 1 1
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 2 2
Substance-P receptor ligand AGN-PC-073MZ3 family 2 0
Aldose reductase inhibitor Spiro-cimqat family 6 8
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Kappa-type opioid receptor and Nociceptin receptor ligand AGN-... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 4
Interleukin-8 inhibitor 2-[2-(2,6-dichloroanilino)phenyl]-N-me... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Transient receptor potential cation channel subfamily A member... 1 0
Thioredoxin glutathione reductase and Nonstructural protein 1 ... 1 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Proteinase-activated receptor 1 ligand 2-bromo-N-[3-(butanoyla... 4 0
G protein-activated inward rectifier potassium channel 4 and G... 1 0
Lysophosphatidic acid receptor 3 and Microtubule-associated pr... 1 1
Substance-P receptor ligand AGN-PC-01XQZB family 1 0
ylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indo... 20 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00305094 CHEMBL262068 Bioactive 3-[5-[4-(4-chlorophenyl)piperazin-1-yl]pentyl]-3-ethyl-1H-indol-2-one
CFAMM00305053 CHEMBL349833 Bioactive CHEMBL349833
CFAMM00305169 CHEMBL259215 Bioactive 7-chloro-3-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-5-fluoro-1H-indol-2-one
CFAMM00305196 CHEMBL106916 Bioactive AGN-PC-074VAD
CFAMM00305274 CHEMBL352207 Bioactive CHEMBL352207
CFAMM00305328 CHEMBL411919 Bioactive 5-chloro-3-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one
CFAMM00305022 CHEMBL259010 Bioactive 3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-5-fluoro-1H-indol-2-one
CFAMM00305140 CHEMBL330108 Bioactive AGN-PC-074OEM
CFAMM00305058 CHEMBL258496 Bioactive 3-[5-[4-(3-chlorophenyl)piperazin-1-yl]pentyl]-3-ethyl-1H-indol-2-one
CFAMM00305244 CHEMBL408450 Bioactive 3-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-5-fluoro-1,3-dihydroindol-2-one
CFAMM00305167 CHEMBL406414 Bioactive 3-[4-[4-(3-chloro-4-fluorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one
CFAMM00305181 CHEMBL104832 Bioactive AGN-PC-074V6W
CFAMM00305027 CHEMBL259009 Bioactive 5,7-dichloro-3-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one
CFAMM00305118 CHEMBL259549 Bioactive 3-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-6-fluoro-1H-indol-2-one
CFAMM00305326 CHEMBL410226 Bioactive 3-[4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]butyl]-3-ethyl-1H-indol-2-one
CFAMM00305291 CHEMBL321201 Bioactive 2-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1-[(2R)-2-methyl-2,3-dihydroindol-1-yl]ethanone
CFAMM00305159 CHEMBL261009 Bioactive 5-chloro-3-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-6-fluoro-1H-indol-2-one
CFAMM00305236 CHEMBL259086 Bioactive 3-[4-[4-(3-chloro-4-methylphenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one
CFAMM00305019 CHEMBL104323 Bioactive 2-[4-[(4-chloro-2,5-difluorophenyl)methyl]piperazin-1-yl]-1-[(2R)-2-methyl-2,3-dihydroindol-1-yl]ethanone
CFAMM00305062 CHEMBL408191 Bioactive 3-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-3-(2-methylpropyl)-1H-indol-2-one
CFAMM00305228 CHEMBL125079 Bioactive SureCN4528082
CFAMM00305025 CHEMBL104788 Bioactive SureCN7659719
CFAMM00305235 CHEMBL259087 Bioactive 3-[4-[4-(3,4-dichlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one
CFAMM00305171 CHEMBL269083 Bioactive 5-chloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one
CFAMM00305213 CHEMBL314952 Bioactive 4-(4-benzylpiperazin-1-yl)-1,3-dihydroindol-2-one
CFAMM00305087 CHEMBL322326 Bioactive AGN-PC-074VHJ
CFAMM00305010 CHEMBL260551 Bioactive 5-chloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-6-fluoro-1H-indol-2-one
CFAMM00305067 CHEMBL261719 Bioactive 3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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