CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4259
Family Name Type-2 angiotensin II receptor Ligand Macrocyclic Quinazolinone Analogue Family
No. of Seeds 32 No. of Other Members 49
Family Centroid CFAMM00305518 Functional Category Investigative Drug
Superfamily Type-2 angiotensin II receptor Ligand Macrocyclic Quinazolinone Analogue Superfamily
Class Class 3048

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Type-1B angiotensin II receptor and Type-1 angiotensin II rece... 16 0
Type-2 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Collagenase 3 inhibitor 4-[[4-oxo-6-(3-phenylprop-1-ynyl)quina... 1 0


External ID

Functional Category

Molecule Name

CFAMM00305482 CHEMBL352502 Bioactive AGN-PC-0757HT
CFAMM00305526 CHEMBL164395 Bioactive N-[2-[4-[[6-(dimethylamino)-4-oxo-2-propylquinazolin-3-yl]methyl]phenyl]phenyl]sulfonylbenzamide
CFAMM00305447 CHEMBL74476 Bioactive butyl N-[2-[4-[[2-butyl-6-[[methyl(propan-2-yl)carbamoyl]amino]-4-oxoquinazolin-3-yl]methyl]phenyl]phenyl]sulfonylcarbamate
CFAMM00305519 CHEMBL168413 Bioactive AGN-PC-072NKS
CFAMM00305454 CHEMBL263714 Bioactive CHEMBL263714
CFAMM00305467 CHEMBL74556 Bioactive AGN-PC-074J2L
CFAMM00305481 CHEMBL354779 Bioactive AGN-PC-0757HN
CFAMM00305510 CHEMBL169568 Bioactive AGN-PC-0757JZ
CFAMM00305500 CHEMBL74442 Bioactive AGN-PC-00OS4X
CFAMM00305480 CHEMBL169221 Bioactive AGN-PC-072NKP
CFAMM00305509 CHEMBL350554 Bioactive 2-methylpropyl N-[3-[[4-[2-(benzoylsulfamoyl)phenyl]phenyl]methyl]-4-oxo-2-propylquinazolin-6-yl]-N-methylcarbamate
CFAMM00305459 CHEMBL367569 Bioactive CHEMBL367569
CFAMM00305515 CHEMBL168771 Bioactive AGN-PC-0757OM
CFAMM00305452 CHEMBL169279 Bioactive 4-methylpentyl N-[2-[4-[[6-(morpholine-4-carbonylamino)-4-oxo-2-propylquinazolin-3-yl]methyl]phenyl]phenyl]sulfonylcarbamate
CFAMM00305507 CHEMBL164769 Bioactive 2-methylpropyl N-[2-butyl-3-[[4-[2-(cyclopropanecarbonylsulfamoyl)phenyl]phenyl]methyl]-4-oxoquinazolin-6-yl]-N-methylcarbamate
CFAMM00305458 CHEMBL169488 Bioactive AGN-PC-0757MW
CFAMM00305523 CHEMBL352947 Bioactive AGN-PC-0757KI
CFAMM00305485 CHEMBL352629 Bioactive AGN-PC-0757KH
CFAMM00305514 CHEMBL353800 Bioactive butyl N-[2-[4-[[2-butyl-4-oxo-6-(propan-2-ylcarbamoylamino)quinazolin-3-yl]methyl]phenyl]phenyl]sulfonylcarbamate
CFAMM00305529 CHEMBL169967 Bioactive AGN-PC-0757HD
CFAMM00305478 CHEMBL408798 Bioactive CHEMBL408798
CFAMM00305491 CHEMBL368149 Bioactive AGN-PC-072OE3
CFAMM00305506 CHEMBL354080 Bioactive 3,3-dimethylbutyl N-[2-[4-[[6-(ethylcarbamoylamino)-4-oxo-2-propylquinazolin-3-yl]methyl]phenyl]phenyl]sulfonylcarbamate
CFAMM00305457 CHEMBL353615 Bioactive AGN-PC-072NKO
CFAMM00305484 CHEMBL353980 Bioactive AGN-PC-0757HS
CFAMM00305450 CHEMBL168490 Bioactive AGN-PC-072NKT
CFAMM00305513 CHEMBL76821 Bioactive AGN-PC-074J7W
CFAMM00305477 CHEMBL408799 Bioactive AGN-PC-072ODY
CFAMM00305456 CHEMBL169009 Bioactive butyl N-[2-[4-[(6-amino-4-oxo-2-propylquinazolin-3-yl)methyl]phenyl]phenyl]sulfonylcarbamate
CFAMM00305469 CHEMBL415073 Bioactive AGN-PC-074IWP
CFAMM00305483 CHEMBL352503 Bioactive AGN-PC-0757HU
CFAMM00305476 CHEMBL353037 Bioactive AGN-PC-072NKR

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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