CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4263
Family Name Trypsin Inhibitor Benzamidrazone Analogue Family
No. of Seeds 16 No. of Other Members 6
Family Centroid CFAMM00305581 Functional Category Investigative Drug
Superfamily Suppressor of tumorigenicity 14 protein and Trypsin Binder Superfamily
Class Class 1568

Cousin Family NamesSeedsMembers
Cathepsin K Inhibitor Odanacatib Family 33 84
Upamostat family 1 13
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Prothrombin Inhibitor LB30812 Family 12 36
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Coagulation factor X inhibitor (6S,8aS)-2-benzhydrylsulfonyl-N... 5 5
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Prothrombin and Cationic trypsin inhibitor 2-[butyl-[(2S)-4-[[... 7 32
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Coagulation factor X and Trypsin-1 inhibitor SureCN6161266 family 2 28
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
B1 bradykinin receptor ligand SureCN13936521 family 19 4
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Suppressor of tumorigenicity 14 protein and Plasminogen inhibi... 10 15
B1 bradykinin receptor and B2 bradykinin receptor ligand SureC... 3 0
Prothrombin and Cationic trypsin inhibitor (2S)-N-[[4-[(Z)-C-a... 6 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Prothrombin and Cationic trypsin inhibitor (2S)-3-(5-carbamimi... 2 0
Trypsin-1 inhibitor (2R)-1-[(2S)-3-(4-carbamimidoylphenyl)-2-[... 1 0
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Prothrombin inhibitor (2S)-3-[4-[amino(hydrazinyl)methyl]pheny... 1 0
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00305583 CHEMBL82072 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]-2-fluorophenyl]-N-cyclopentyl-N-methyl-2-(naphthalen-2-ylsulfonylamino)propanamide
CFAMM00305589 CHEMBL120950 Bioactive 2-[4-[(Z)-C-aminocarbonohydrazonoyl]phenyl]-N-cyclopentyl-N-methyl-2-(naphthalen-2-ylsulfonylamino)acetamide
CFAMM00305582 CHEMBL269206 Bioactive (2S)-3-[4-[amino(hydrazinyl)methyl]phenyl]-N-cyclopentyl-N-methyl-2-(naphthalen-2-ylsulfonylamino)propanamide
CFAMM00305571 CHEMBL9582 Bioactive (2S)-3-[4-[amino(hydrazinyl)methyl]phenyl]-N-cyclopentyl-N-methyl-2-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-ylsulfonylamino)propanamide
CFAMM00305588 CHEMBL82057 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]phenyl]-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)propanamide
CFAMM00305577 CHEMBL83205 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]-3-fluorophenyl]-N-cyclopentyl-N-methyl-2-(naphthalen-2-ylsulfonylamino)propanamide
CFAMM00305569 CHEMBL314189 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]-3-fluorophenyl]-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)propanamide
CFAMM00305576 CHEMBL156082 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]phenyl]-N-cyclopentyl-N-ethyl-2-(naphthalen-2-ylsulfonylamino)propanamide
CFAMM00305568 CHEMBL9463 Bioactive (2S)-3-[4-[amino(hydrazinyl)methyl]phenyl]-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)propanamide
CFAMM00305575 CHEMBL313296 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]-2-fluorophenyl]-N-cyclopentyl-N-methyl-2-[(4-propylphenyl)sulfonylamino]propanamide
CFAMM00305592 CHEMBL353818 Bioactive N'-amino-4-[(2S)-2-(anthracen-2-ylsulfonylamino)-3-(azepan-1-yl)-3-oxopropyl]benzenecarboximidamide
CFAMM00305567 CHEMBL347158 Bioactive N'-amino-4-[(2S)-3-(azepan-1-yl)-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide
CFAMM00305574 CHEMBL84454 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]-2-fluorophenyl]-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)propanamide
CFAMM00305591 CHEMBL310664 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]phenyl]-N-cyclopentyl-N-methyl-2-[(4-propylphenyl)sulfonylamino]propanamide
CFAMM00305573 CHEMBL312011 Bioactive (2S)-3-[4-[(Z)-C-aminocarbonohydrazonoyl]-3-fluorophenyl]-N-cyclopentyl-N-methyl-2-[(4-propylphenyl)sulfonylamino]propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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