CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID434
Family Name Extracellular calcium-sensing receptor Ligand Nps 568 Family
No. of Seeds 5 No. of Other Members 54
Family Centroid CFAMM00191153 Functional Category Investigative Drug with Natural Product
Superfamily Extracellular calcium-sensing receptor Ligand Nps 568 Superfamily
Class Class 120

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
CORT-108297 family 46 44
Dapoxetine family 3 40
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
DNA-dependent protein kinase catalytic subunit Inhibitor 6-chl... 2 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 9
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 10 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 3 4
Substance-P receptor ligand (2S,3S)-2-(3-chlorophenyl)-N-[(2,4... 1 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 11 4
Prostaglandin D2 receptor 2 ligand SureCN1713638 family 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 4 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-073O5X family 3 1
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Sodium-dependent serotonin transporter inhibitor 4-(4-chloro-2... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent serotonin transporter and Potassium voltage-g... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Substance-P receptor ligand SureCN6400808 family 2 0
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 1
Sodium-dependent dopamine transporter and Transporter inhibito... 4 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Sterol O-acyltransferase 1 inhibitor AGN-PC-073SE1 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00191162 CHEMBL437075 Bioactive SureCN6554985
CFAMM00191168 CHEMBL513629 Bioactive AGN-PC-078WIP
CFAMM00191142 CHEMBL507721 Bioactive AGN-PC-06OW1K
CFAMM00191160 DNC001190 Investigative Drug R-568
CFAMM00191153 DNC001042 Investigative Drug NPS 568

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27047 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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