CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID437
Family Name Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family
No. of Seeds 2 No. of Other Members 83
Family Centroid CFAMM00191223 Functional Category Investigative Drug with Natural Product
Superfamily Dihydroorotate dehydrogenase and 5-hydroxytryptamine receptor 2A Binder Superfamily
Class Class 59

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Lethal factor Inhibitor GM6001 Family 50 435
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibi... 2 5
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
Melanin-concentrating hormone receptor 2 ligand (2R)-1'-(9H-ca... 2 10
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Coagulation factor X inhibitor N-[(1R,2S,5S)-2-[(5-bromo-1H-in... 1 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6080935 f... 1 0
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 1 0
(4aR,13bS,14aR)-3,4,4a,5,7,8,13,13b,14,14a-decahydro-5,14-etha... 2 0
8'-fluoro-6'-methyl-2,3,4,5',6',9-hexahydrodispiro[beta-carbol... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00191242 CHEMBL1934128 Bioactive N-[(1R)-1'-[(6-bromo-9H-carbazol-3-yl)methyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide
CFAMM00191223 DNC001048 Investigative Drug NSC 665564

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27514 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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