CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID443
Family Name Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2h-chromene-3-carboxamido)benzoate Family
No. of Seeds 4 No. of Other Members 117
Family Centroid CFAMM00191529 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Amyloid beta A4 protein and Amine oxidase [flavin-containing] A Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Proparacain... 2 26
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
Histamine H1 receptor and Histamine H3 receptor Ligand GSK8357... 2 2
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Substance-K receptor Ligand SLV-332 Family 1 1
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Receptor tyrosine-protein kinase erbB-2 Inhibitor Mini-antibod... 1 0
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
Histone deacetylase 2 Inhibitor N-(2-amino-5-(furan-2-yl)pheny... 3 7
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 4 ligand AGN-PC-087VMU family 1 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
Androgen receptor ligand (6R,7R)-6,7-diethyl-4-(trifluoromethy... 15 20
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 11 26
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor ethyl ... 3 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 3
Androgen receptor ligand trifluoromethyl 10-methoxy-4-methyl-2... 2 57
Androgen receptor ligand 10-(hydroxymethyl)-4-methyl-1,5-dihyd... 2 2
Androgen receptor ligand tert-butyl 4-methyl-2,5-dioxo-1H-chro... 3 0
Capsid scaffolding protein inhibitor AC1MHP1L family 3 6
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7496449 f... 3 2
Acrosin and Trypsin-1 inhibitor (4-chlorophenyl) 4-(diaminomet... 2 4
Urokinase-type plasminogen activator and Trypsin-1 inhibitor A... 1 6
Pol polyprotein inhibitor AC1LA3B0 family 1 2
Prostaglandin E2 receptor EP1 subtype ligand 3-acetamido-5-[2-... 5 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Beta-3 adrenergic receptor ligand 4-[4-[2-[[(2R)-2-(4-aminophe... 3 0
Bifunctional epoxide hydrolase 2 inhibitor [3-(1-adamantylcarb... 1 0
Bifunctional epoxide hydrolase 2 inhibitor Urea-based compound... 1 3
Carbonic anhydrase 2 and Carbonic anhydrase 12 inhibitor F2838... 2 6
Capsid scaffolding protein inhibitor AC1MHP20 family 3 3
Neuropeptide Y receptor type 1 ligand 1-(1-benzofuran-6-yl)-3-... 1 1
Retinoic acid receptor RXR-gamma and Retinoic acid receptor RX... 3 36
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 2 0
Trace amine-associated receptor 1 ligand ZINC07609882 family 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8797384 f... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Follicle-stimulating hormone receptor ligand (1-acetyl-2,2,4-t... 1 2
Transient receptor potential cation channel subfamily V member... 2 7
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Mitogen-activated protein kinase 14 inhibitor SureCN4222090 fa... 1 12
Cathepsin K and Cathepsin B inhibitor N-[1-[[cyano(methyl)amin... 1 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 3
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Progesterone receptor ligand AGN-PC-00PB7I family 1 5
Multidrug resistance protein 1 inhibitor UNII-05D072FS97 family 1 3
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 4
Huntingtin and Retinal dehydrogenase 1 inhibitor CHEMBL1467512... 1 0
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 1
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 2 1
NAD-dependent protein deacetylase sirtuin-2 inhibitor 2-[3-[2-... 1 0
Malate dehydrogenase, mitochondrial and Lactate dehydrogenase ... 1 1
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
2-carboxy-5-[[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]amino]p... 1 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
(5S)-5-methyl-3-(2-oxochromen-7-yl)imidazolidine-2,4-dione NP ... 1 0
2-(1'-acetyl-4-oxospiro[3H-chromene-2,4'-piperidine]-7-yl)oxya... 5 1
methyl 2-[(7-bromo-1-benzoxepine-4-carbonyl)amino]benzoate NP ... 1 0
Putative NP ZINC08880095 Family 2 0
Putative NP ZINC17112928 Family 5 0
bromo-N-[2-(4-tert-butylphenyl)-4-oxochromen-7-yl]benzamide NP... 4 0
1-benzofuran-3-one NP ZINC11865075 Family 2 0
2-chloro-N-[2-(4-ethoxyphenyl)-4-oxochromen-7-yl]benzamide NP ... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00191530 DNC009099 Investigative Drug 4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid
CFAMM00191529 DNC009098 Investigative Drug ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate
CFAMM00191466 DNC001069 Investigative Drug Otilonium bromide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22656 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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