CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID451
Family Name Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibitor PD0183813 Family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00191678 Functional Category Investigative Drug
Superfamily Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibitor PD0183813 Superfamily
Class Class 1031

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Receptor-type tyrosine-protein kinase FLT3 ligand 4-[6-amino-5... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00191679 CHEMBL143534 Bioactive AC1NS8PA
CFAMM00191678 DNC001095 Investigative Drug PD0183813

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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