CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID460
Family Name 5-hydroxytryptamine receptor 1A Ligand P-MPPI Family
No. of Seeds 33 No. of Other Members 81
Family Centroid CFAMM00192535 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and Peptidyl-prolyl cis-trans isomerase A Binder Superfamily
Class Class 1612

Cousin Family NamesSeedsMembers
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
E7050 family 2 13
Serine/threonine-protein kinase Chk1 Inhibitor LY2603618 Family 2 1
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Coagulation factor X and Neutrophil elastase Inhibitor ZK-8140... 51 17
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 2
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Survival motor neuron protein and Microtubule-associated prote... 2 14
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QM67 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
5-hydroxytryptamine receptor 3A ligand 6-methyl-5-[4-[3-[(2R)-... 12 3
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
5-hydroxytryptamine receptor 1A ligand 4-chloro-N-[(2S)-2-[4-(... 4 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940907 family 2 21
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940986 family 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 1 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 2
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 9
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 5 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 5
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 2
Peroxisome proliferator-activated receptor gamma and Cytochrom... 1 1
Cathepsin S and Cathepsin L1 inhibitor AGN-PC-077QOL family 1 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
Histamine H3 receptor ligand AGN-PC-03Z8HB family 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Hydroxycarboxylic acid receptor 2 and Hydroxycarboxylic acid r... 2 3
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0
D(2) dopamine receptor ligand AGN-PC-00NWZH family 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
Metabotropic glutamate receptor 5 ligand 2-oxo-N-pyridin-2-yl-... 1 0
4-oxo-N-(6-((1R,5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2... 1 0
5-(4-methoxyphenyl)-4-oxo-1H-pyrido[2,3-d]pyrimidin-2-olate NP... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00192495 CHEMBL286607 Bioactive 155204-26-5
CFAMM00192501 CHEMBL137298 Bioactive N-[2-[4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide
CFAMM00192459 CHEMBL1774992 Bioactive AGN-PC-09OF5X
CFAMM00192476 CHEMBL416398 Bioactive 3-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide
CFAMM00192509 CHEMBL343310 Bioactive 4-ethyl-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide
CFAMM00192522 CHEMBL1774990 Bioactive AGN-PC-09OF4T
CFAMM00192555 CHEMBL38413 Bioactive SureCN4636179
CFAMM00192508 CHEMBL90874 Bioactive N-tert-butyl-2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]pyridine-3-carboxamide
CFAMM00192521 CHEMBL1774991 Bioactive AGN-PC-00COOB
CFAMM00192540 CHEMBL88512 Bioactive 2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]pyridine-3-carboxamide
CFAMM00192457 CHEMBL1910141 Bioactive 1-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbicyclo[2.2.1]heptane-4-carboxamide
CFAMM00192575 CHEMBL93054 Bioactive 2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-N-methylpyridine-3-carboxamide
CFAMM00192467 CHEMBL143830 Bioactive 4-(chloromethyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide
CFAMM00192520 CHEMBL1774993 Bioactive AGN-PC-09OF5Y
CFAMM00192456 CHEMBL1910140 Bioactive 1-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbicyclo[2.2.2]octane-4-carboxamide
CFAMM00192473 CHEMBL1910138 Bioactive 3-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-yladamantane-1-carboxamide
CFAMM00192574 CHEMBL410521 Bioactive SureCN8011055
CFAMM00192479 CHEMBL30758 Bioactive SureCN898147
CFAMM00192472 CHEMBL1910139 Bioactive 4-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcubane-1-carboxamide
CFAMM00192559 CHEMBL43297 Bioactive 4-fluoro-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-3-methyl-N-pyridin-2-ylbenzamide
CFAMM00192573 CHEMBL1628682 Bioactive N-pyridin-2-yl-N-[2-[4-[2-(tritritiomethoxy)phenyl]piperazin-1-yl]ethyl]bicyclo[2.2.2]octane-3-carboxamide
CFAMM00192566 CHEMBL342198 Bioactive N-[2-[4-[2-(3-fluoropropoxy)phenyl]piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide
CFAMM00192543 CHEMBL140697 Bioactive N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-4-methyl-N-pyridin-2-ylbenzamide
CFAMM00192460 CHEMBL143869 Bioactive 4-amino-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide
CFAMM00192505 DNC001509 Investigative Drug WAY-100635
CFAMM00192535 DNC001136 Investigative Drug P-MPPI

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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