CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family
No. of Seeds 4 No. of Other Members 13
Family Centroid CFAMM00192613 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Superfamily
Class Class 1614

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family 22 503
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Vitamin K epoxide reductase complex subunit 1 Inhibitor Phenin... 5 44
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
DNA topoisomerase 1 Inhibitor Beta-lapachone Family 3 66
CPI-613 family 4 35
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,3,6-trifluorophen... 16 11
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Glutamate carboxypeptidase 2 Inhibitor 2-(3-cyanobenzyl)-5-mer... 1 0
Thyroid hormone receptor beta Ligand (4-hexylphenyl)(oxiran-2-... 1 16
Liver carboxylesterase 1 Inhibitor Acenanthrene-9,10-dione Family 2 12
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-methoxy-1,4-naphthoq... 1 3
4-hydroxyphenylpyruvate dioxygenase Inhibitor 2-(2-iodo-benzoy... 3 1
Thyrotropin receptor and Retinal dehydrogenase 1 ligand NINHYD... 1 1
Microtubule-associated protein tau and Putative fructose-1,6-b... 1 1


External ID

Functional Category

Molecule Name

CFAMM00192609 CHEMBL1317916 Bioactive NSC98019
CFAMM00192608 CHEMBL2408238 Bioactive 2-hydroxy-3-naphthalen-2-ylcyclohepta-2,4,6-trien-1-one
CFAMM00192613 DNC001140 Investigative Drug Polyporic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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