CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID47
Family Name Dipeptidyl peptidase 4 Inhibitor Denagliptin Family
No. of Seeds 24 No. of Other Members 151
Family Centroid CFAMM00176005 Functional Category Investigative Drug
Superfamily Dipeptidyl peptidase 4 Inhibitor Denagliptin Superfamily
Class Class 1224

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Opioid receptor Ligand Methadone Family 3 39
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 2 9
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Cathepsin K Inhibitor Odanacatib Family 33 84
Dopamine reuptake Inhibitor Amineptine Family 2 5
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 3
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Substance-P receptor Ligand Vestipitant Family 14 137
Bavisant family 9 65
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor LB30812 Family 12 36
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor Ppack Family 5 4
Neuromedin-K receptor Ligand Senktide Family 15 22
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 1 3
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(2-... 1 1
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Prothrombin and Coagulation factor X inhibitor AGN-PC-074UE2 f... 1 0
Pol polyprotein inhibitor penicillin deriv. 49 family 3 19
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 5 9
Pol polyprotein inhibitor penicillin deriv. 38 family 1 1
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Prolyl endopeptidase inhibitor SureCN194654 family 3 4
B2 bradykinin receptor ligand SureCN13864840 family 1 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 2 0
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 4 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 2 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S,5S)-4-(1,3-dih... 3 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 2
Substance-P receptor and Neuromedin-K receptor ligand (3R,4S)-... 2 2
Substance-P receptor and Neuromedin-K receptor ligand N-[(3R,4... 2 0
Prothrombin inhibitor SureCN7341151 family 6 7
Oxytocin receptor and Vasopressin V1a receptor ligand L 365209... 6 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Prothrombin inhibitor (2S)-N-[4-(2-amino-2-iminoethyl)cyclohex... 2 0
Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acety... 15 9
Substance-P receptor ligand AGN-PC-075NRR family 2 1
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 0
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Endothelin-converting enzyme 1 and Neprilysin inhibitor (2S)-2... 1 8
Neprilysin inhibitor SureCN489232 family 3 9
Cathepsin S inhibitor SureCN7062841 family 7 7
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpip... 6 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Neutrophil collagenase and Collagenase 3 inhibitor n-[[2-methy... 1 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5... 6 6
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-(... 1 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-2-[4-(4-fluor... 1 0
Sigma non-opioid intracellular receptor 1 ligand (10aS)-2-(2-p... 1 2
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 7 3
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 5
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-4-[(3S)-3-flu... 1 5
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 3 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 4 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 2 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Cationic trypsin and Prothrombin inhibitor (2S)-N-[(2S)-5-(dia... 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 162
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Cationic trypsin and Prothrombin inhibitor (3S,6S)-6-amino-6-b... 4 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Alpha-1A adrenergic receptor and Histamine H1 receptor ligand ... 13 1
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-(naphthalen-2... 3 1
Prolyl endopeptidase inhibitor 1-[(4R)-4-(pyrrolidine-1-carbon... 11 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 1
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Prolyl endopeptidase inhibitor [(2S)-2-(pyrrolidine-1-carbonyl... 3 0
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Sigma non-opioid intracellular receptor 1 ligand tert-butyl N-... 1 9
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 13
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Melanocortin receptor 4 ligand 3-[[1-[(3R,4S)-1-tert-butyl-4-(... 1 0
Prothrombin inhibitor [(1R)-4-carbamimidoylsulfanyl-1-[[2-[met... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[2-(3-methy... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Histamine H3 receptor ligand [(3aR,6aR)-4-[4-[2-[(2R)-2-methyl... 6 0
Sodium-dependent noradrenaline transporter and Muscarinic acet... 1 2
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Growth hormone secretagogue receptor type 1 ligand [(3R)-3-ami... 2 5
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 3 4
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Prothrombin inhibitor 1-(2-amino-3,3-diphenylpropanoyl)-N-[(3-... 1 1
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Glucose-dependent insulinotropic receptor ligand (1-methylcycl... 4 3
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Histone deacetylase 8 and Histone deacetylase 1 inhibitor tert... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor Su... 6 5
Papain and Cathepsin S inhibitor dipeptide-derived nitrile, 28... 1 2
Dipeptidyl peptidase 4 inhibitor 5-[4-[(2S,3S)-3-amino-4-[(3S)... 2 0
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1
Histamine H3 receptor ligand (2S)-N-(2,3-dihydro-1H-inden-2-yl... 2 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
Cathepsin L1 inhibitor (2R)-2-[[3-benzylsulfanyl-2-[[2-(4-phen... 1 0
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 2 2
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 6 4
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor et... 1 0
Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN14523901 family 7 1
Genome polyprotein inhibitor Benzoyl-KKR-H family 1 1
Dipeptidyl peptidase 4 inhibitor (2S,4S)-4-fluoro-1-[2-[[(E)-2... 1 0
Prolyl endopeptidase inhibitor 3eq9 family 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 2 0
carboxamide NP (s)-n1-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)... 2 0
NP Tert-butyl ((s)-1-oxo-1-((1r,5s)-8-oxo-5,6-dihydro-1h-1,5-m... 1 0
NP (s,e)-3-benzylidenehexahydropyrrolo[1,2-a]pyrazine-1,4-dion... 2 2
4-[[[1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pheny... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00176057 CHEMBL199905 Bioactive (2S)-1-[(2S)-2-amino-3-[4-(2,4-difluorophenyl)phenyl]propanoyl]pyrrolidine-2-carbonitrile
CFAMM00175918 CHEMBL191258 Bioactive (2S,3S)-2-amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-pyrrolidin-1-ylbutane-1,4-dione;2,2,2-trifluoroacetic acid
CFAMM00176037 CHEMBL550321 Bioactive N-[[(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl]-N,2,2-trimethylpropanamide
CFAMM00175988 CHEMBL557723 Bioactive N-[[(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl]cyclopentanecarboxamide
CFAMM00176017 CHEMBL334727 Bioactive (2S)-N-[(4-aminocyclohexyl)methyl]-1-(3-phenylheptanoyl)pyrrolidine-2-carboxamide
CFAMM00175938 CHEMBL1078066 Bioactive (2S,4R)-N-[(1S)-1-cyano-2-phenylethyl]-4-methylsulfanyl-4-phenylpyrrolidine-2-carboxamide
CFAMM00176029 CHEMBL190466 Bioactive (2S,3S)-3-amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide;2,2,2-trifluoroacetic acid
CFAMM00176035 CHEMBL564105 Bioactive SureCN14282742
CFAMM00175986 CHEMBL2396664 Bioactive (2S,3S)-1-[(2S)-2-amino-3-phenylpropanoyl]-3-phenylpyrrolidine-2-carboxamide
CFAMM00176067 CHEMBL563901 Bioactive N-[[(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl]cyclobutanecarboxamide
CFAMM00175957 CHEMBL189055 Bioactive (2S,3S)-3-amino-4-[(2S)-2-cyanopyrrolidin-1-yl]-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
CFAMM00175895 CHEMBL1270785 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[(3R,4S)-4-(4-fluorophenyl)pyrrolidin-3-yl]-N,2-dimethylpropanamide
CFAMM00175972 CHEMBL396512 Bioactive (2S)-1-[(2S,4R)-4-phenylpyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00175935 CHEMBL2397494 Bioactive (2S)-2-amino-N-[(2S)-1-amino-3-(3-fluorophenyl)-1-oxopropan-2-yl]-3-phenylpropanamide
CFAMM00175971 CHEMBL396513 Bioactive (2S)-1-[(2S,4R)-4-(2,6-dimethylphenyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00176004 CHEMBL199614 Bioactive (2S)-1-[(2S)-2-amino-3-[4-(4-fluorophenyl)phenyl]propanoyl]pyrrolidine-2-carbonitrile
CFAMM00175899 CHEMBL563648 Bioactive SureCN8289115
CFAMM00175976 CHEMBL237119 Bioactive SureCN5251559
CFAMM00175940 CHEMBL1078065 Bioactive (2S,4R)-N-[(1S)-1-cyano-2-phenylethyl]-4-fluoro-4-phenylpyrrolidine-2-carboxamide
CFAMM00176003 CHEMBL199615 Bioactive (2S)-1-[(2S)-2-amino-3-[4-(2-fluorophenyl)phenyl]propanoyl]pyrrolidine-2-carbonitrile
CFAMM00176005 DPR000133 Investigative Drug Denagliptin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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