CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID498
Family Name Vasopeptidase Inhibitor Sampatrilat Family
No. of Seeds 25 No. of Other Members 9
Family Centroid CFAMM00212320 Functional Category Investigative Drug with Natural Product
Superfamily Oxytocin receptor and Vasopressin V2 receptor Binder Superfamily
Class Class 18

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Oxytocin receptor Ligand Oxytocin Family 30 182
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Zucapsacin family 7 177
Thymopentin family 20 133
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Plitidepsin family 15 5
Flovagatran family 12 546
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Vasopeptidase Inhibitor Fasidotril Family 3 7
Neprilysin Inhibitor Thiorphan Family 41 68
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Neuromedin-K receptor Ligand Senktide Family 15 22
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Caspase-1 Inhibitor Yvad Family 1 0
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Kynureninase Inhibitor 3-hydroxyhippuric Acid Family 1 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Integrin beta-3 Inhibitor Lamifiban Family 3 4
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 9
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6368456 f... 3 23
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-3-[fo... 2 0
Tyrosine--tRNA ligase, cytoplasmic inhibitor (2S)-2-[[(2S)-2-a... 5 2
Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-s... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Plasminogen inhibitor (2S)-2-acetamido-5-(diaminomethylideneam... 1 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 3 0
Oxytocin receptor ligand (2S)-N-[(2R)-1-[2-[[5-amino-1-[[1-ami... 4 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Metallo-beta-lactamase L1 inhibitor 3-[[1-[[(2R)-1-amino-1-oxo... 1 0
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Neurotensin receptor type 1 ligand (2S)-2-[[(2S,3S)-2-[[(2S)-2... 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
C-X-C chemokine receptor type 4 ligand CHEMBL2372990 family 3 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Angiotensin-converting enzyme inhibitor Rentiapril family 1 7
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Sodium-dependent dopamine transporter inhibitor AC1MIIGH family 2 0
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
Growth factor receptor-bound protein 2 ligand 2-[[(5S,8S,11S,1... 2 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00212340 CHEMBL275817 Bioactive (8S,13R)-13-[[1-acetyl-3-(4-hydroxyphenyl)pyrrolidine-2-carbonyl]amino]-6,14-dioxo-11-thia-7,15-diazaspiro[4.12]heptadecane-8-carboxylic acid
CFAMM00212346 CHEMBL276353 Bioactive (4R,12R)-12-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7,7-diethyl-6,11-dioxo-1,2-dithia-5,10-diazacyclotridecane-4-carboxylic acid
CFAMM00212339 CHEMBL326539 Bioactive (3S,6R,11R,14S)-6-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-(hydroxymethyl)-2,5,13-trioxo-8,9-dithia-1,4,12-triazabicyclo[12.3.0]heptadecane-11-carboxylic acid
CFAMM00212332 CHEMBL325410 Bioactive (3S,6R,11R,14S)-6-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(carboxymethyl)-2,5,13-trioxo-8,9-dithia-1,4,12-triazabicyclo[12.3.0]heptadecane-11-carboxylic acid
CFAMM00212345 CHEMBL275603 Bioactive (8R,13R)-13-[[1-acetyl-3-(4-hydroxyphenyl)pyrrolidine-2-carbonyl]amino]-6,14-dioxo-10,11-dithia-7,15-diazaspiro[4.12]heptadecane-8-carboxylic acid
CFAMM00212325 CHEMBL432796 Bioactive (3S,6R,11R,14S)-6-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-2,5,13-trioxo-8,9-dithia-1,4,12-triazabicyclo[12.4.0]octadecane-11-carboxylic acid
CFAMM00212338 CHEMBL16742 Bioactive (8R,13R)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-6,14-dioxo-10,11-dithia-7,15-diazaspiro[4.11]hexadecane-8-carboxylic acid
CFAMM00212331 CHEMBL333631 Bioactive (3S,6R,11R,14S)-6-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-2,5,13-trioxo-8,9-dithia-1,4,12-triazabicyclo[12.3.0]heptadecane-11-carboxylic acid
CFAMM00212324 CHEMBL278199 Bioactive (8R,13R)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-6,14-dioxo-10,11-dithia-7,15-diazaspiro[4.12]heptadecane-8-carboxylic acid
CFAMM00212337 CHEMBL1794012 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-methyl-2-[[(2S,3S)-3-methyl-2-sulfanylpentanoyl]amino]butanoyl]amino]propanoic acid
CFAMM00212330 CHEMBL16710 Bioactive (8R,13R)-13-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-6,14-dioxo-10,11-dithia-7,15-diazaspiro[4.12]heptadecane-8-carboxylic acid
CFAMM00212343 CHEMBL2372105 Bioactive (3S,6R,11R,14S)-6-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-(carboxymethyl)-2,5,13-trioxo-8,9-dithia-1,4,12-triazabicyclo[12.3.0]heptadecane-11-carboxylic acid
CFAMM00212336 CHEMBL68583 Bioactive SureCN9241543
CFAMM00212329 CHEMBL320610 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[1-[[(2S)-3-methyl-2-sulfanylbutanoyl]amino]cyclopentanecarbonyl]amino]propanoic acid
CFAMM00212321 CHEMBL17300 Bioactive (8R,13S)-13-[[1-acetyl-3-(4-hydroxyphenyl)pyrrolidine-2-carbonyl]amino]-6,14-dioxo-10-thia-7,15-diazaspiro[4.12]heptadecane-8-carboxylic acid
CFAMM00212335 CHEMBL20341 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S,3R)-3-methyl-2-[[(2S)-3-methyl-2-sulfanylbutanoyl]amino]pentanoyl]amino]propanoic acid
CFAMM00212328 CHEMBL16475 Bioactive (3R,6S,11S,14R)-6-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-(carboxymethyl)-2,5,13-trioxo-8,9-dithia-1,4,12-triazabicyclo[12.3.0]heptadecane-11-carboxylic acid
CFAMM00212320 DNC001270 Investigative Drug Sampatrilat

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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