CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID5
Family Name Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogaine Family
No. of Seeds 3 No. of Other Members 21
Family Centroid CFAMM00173675 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogaine Superfamily
Class Class 731

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Apricoxib family 8 77
Indeglitazar family 3 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Transient receptor potential cation channel subfamily V member... 1 5
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Indoles Metabolite Mukeic acid Family 1 1
Indoles Metabolite Murrastifoline F Family 1 0
1-[4-methoxy-3-[(3-methyl-4-nitrophenoxy)methyl]phenyl]-2,3,4,... 6 0
1-(7-methyl-4-oxochromen-3-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,... 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00173675 DNC000765 Investigative Drug Ibogaine
CFAMM00173685 DPR000010 Investigative Drug ADX-2 series
CFAMM00173684 DNC014492 Investigative Drug VOACANGINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46118 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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