CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID503
Family Name 5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family
No. of Seeds 11 No. of Other Members 121
Family Centroid CFAMM00212649 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 6 Ligand Sb 258585 Superfamily
Class Class 1633

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dp-b99 family 1 5
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 6 Ligand SB-357134 Family 13 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 20 33
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Oestrogen receptor Ligand N-butyl-4-hydroxy-n-phenylbenzenesul... 9 21
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Pyruvate kinase PKLR and Pyruvate kinase PKM inhibitor AGN-PC-... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
5-hydroxytryptamine receptor 6 ligand N-(3,5-dichlorophenyl)-4... 7 2
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
5-hydroxytryptamine receptor 6 ligand 1-(4-methoxy-3-piperazin... 6 3
5-hydroxytryptamine receptor 6 ligand 8-chloro-2-(4-methoxy-3-... 4 1
5-hydroxytryptamine receptor 6 ligand 6-bromo-1-(4-methoxy-3-p... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BRZ7B family 9 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A ligand AGN-PC-0A9RI2 family 2 2
Sigma non-opioid intracellular receptor 1 ligand N-[6-[[5-[3-(... 1 1
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN47965... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN48028... 7 0
Growth hormone secretagogue receptor type 1 ligand SureCN47962... 8 0
Growth hormone secretagogue receptor type 1 ligand SureCN48020... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-met... 3 3
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 6 ligand N-(3-bromo-2,5-dichlorop... 2 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 3-N-hyd... 1 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 3 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00212741 CHEMBL1210711 Bioactive SureCN1725886
CFAMM00212683 CHEMBL234669 Bioactive AGN-PC-0769OE
CFAMM00212738 CHEMBL154089 Bioactive N-(5-iodo-2-methylphenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide
CFAMM00212632 CHEMBL209324 Bioactive NSC708856
CFAMM00212582 CHEMBL292759 Bioactive AC1OCFOP
CFAMM00212703 CHEMBL346338 Bioactive N-(3-iodophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide
CFAMM00212610 CHEMBL1628588 Bioactive 4-iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-1-sulfonamide
CFAMM00212751 CHEMBL157103 Bioactive N-(4-iodophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide
CFAMM00212649 DNC001290 Investigative Drug SB 258585
CFAMM00212646 DNC014873 Investigative Drug SB-258585

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543