CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID53
Family Name Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family
No. of Seeds 11 No. of Other Members 42
Family Centroid CFAMM00176221 Functional Category Investigative Drug
Superfamily Carbonic anhydrase 2 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 1373

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
72 kDa type IV collagenase and Interstitial collagenase Inhibi... 3 15
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Amg 423 family 7 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Class II cytokine receptor Ligand IL-10 Family 7 45
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Transient receptor potential cation channel subfamily V member... 2 26
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-2-ylpi... 1 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-pyridin-2-ylpip... 4 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Cathepsin K inhibitor SureCN4138062 family 7 0
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Dipeptidyl peptidase 4 inhibitor SureCN5777667 family 1 4
Transient receptor potential cation channel subfamily V member... 3 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 3 1
Androgen receptor ligand 4-(1-benzyl-2-oxoimidazo[4,5-b]pyridi... 1 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Dipeptidyl peptidase 4 and Seprase inhibitor SureCN3157261 family 1 0
Hormone-sensitive lipase inhibitor AGN-PC-074W3L family 1 2
Interstitial collagenase inhibitor AGN-PC-03RA86 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00176228 CHEMBL192165 Bioactive 6-[[(3R,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]pyrrolidin-3-yl]amino]pyridine-3-carbonitrile
CFAMM00176241 CHEMBL387297 Bioactive C5-substituted pyrrolidine 40
CFAMM00176220 CHEMBL487680 Bioactive SureCN5206757
CFAMM00176246 CHEMBL1744354 Bioactive (Z)-but-2-enedioic acid;6-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile
CFAMM00176225 CHEMBL418788 Bioactive SureCN6824833
CFAMM00176238 CHEMBL195420 Bioactive 6-[[(3S,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]pyrrolidin-3-yl]amino]pyridine-3-carbonitrile
CFAMM00176224 CHEMBL94598 Bioactive SureCN3816973
CFAMM00176230 CHEMBL94101 Bioactive SureCN3809888
CFAMM00176205 DNC005055 Investigative Drug KR-62436
CFAMM00176221 DNC005423 Investigative Drug NVP-DPP728
CFAMM00176249 DPR000149 Investigative Drug NVP DPP728

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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