CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID539
Family Name 5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family
No. of Seeds 2 No. of Other Members 86
Family Centroid CFAMM00213194 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A Ligand Sun N4057 Superfamily
Class Class 1652

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cytochrome P450 3A4 Inhibitor 3-(5-((methylthio)methyl)furan-2... 4 14
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-345763 Family 1 2
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Renin Inhibitor CP-305202 Family 9 30
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA5M family 4 14
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
Lanosterol synthase inhibitor (4-bromophenyl)-[6-[6-[methyl(pr... 1 1
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 3 68
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 1 13
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 5
Thromboxane-A synthase inhibitor SureCN9045578 family 1 12
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 2
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 2 1
Aromatase inhibitor isoflavone deriv. 5m family 1 0
Platelet-activating factor receptor ligand [(2R,4R)-4-(octadec... 3 2
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 3
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... 2 0
M-phase inducer phosphatase 2 inhibitor NSC663282 family 1 0
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Aldose reductase inhibitor [1-(3,5-difluoro-4-hydroxyphenyl)py... 3 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9RLJ family 1 0
ATP-dependent DNA helicase Q1 and Ras-related protein Rab-9A i... 1 1
Butyrylcholinesterase and Muscarinic acetylcholine receptor M2... 1 0
Indoleamine 2,3-dioxygenase 1 inhibitor CHEMBL576950 family 1 0
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
ylethanone NP (z)-2-(7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoli... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00213133 DNC009080 Investigative Drug WR-190706
CFAMM00213194 DNC001394 Investigative Drug SUN N4057

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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