CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID545
Family Name 5-hydroxytryptamine receptor 4 Ligand TD-5108 Family
No. of Seeds 21 No. of Other Members 24
Family Centroid CFAMM00213301 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 4 Ligand TD-5108 Superfamily
Class Class 1656

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Neuropeptide S receptor ligand AGN-PC-071SSH family 1 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
Neuropeptide Y receptor type 5 ligand 2-(5-fluoro-2,3-dihydroi... 4 3
Kappa-type opioid receptor ligand SureCN5346063 family 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Muscarinic acetylcholine receptor M4 and Potassium voltage-gat... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00213305 CHEMBL555223 Bioactive N-[(1R,5S)-8-[3-[4-(methanesulfonamidomethyl)piperidin-1-yl]propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213311 CHEMBL2087326 Bioactive N-[(1R,5S)-8-[3-(carbamoylamino)-2-hydroxypropyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213330 CHEMBL2087337 Bioactive Velusetrag
CFAMM00213310 CHEMBL2087324 Bioactive N-[(1R,5S)-8-(3-acetamido-2-hydroxypropyl)-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213323 CHEMBL201283 Bioactive SureCN5342035
CFAMM00213315 CHEMBL540981 Bioactive N-[(1R,5S)-8-[7-[4-(methanesulfonamidomethyl)piperidin-1-yl]heptyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213341 CHEMBL565146 Bioactive N-[(1R,5S)-8-[2-(4-methylsulfonylpiperazin-1-yl)ethyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213334 CHEMBL2087333 Bioactive methyl N-[2-hydroxy-3-[(1R,5S)-3-[(2-oxo-1-propan-2-ylquinoline-3-carbonyl)amino]-8-azabicyclo[3.2.1]octan-8-yl]propyl]-N-methylcarbamate
CFAMM00213300 CHEMBL541968 Bioactive N-[(1R,5S)-8-[(2R)-2-hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213340 CHEMBL552075 Bioactive 2-[(1R,5S)-3-[(2-oxo-1-propan-2-ylquinoline-3-carbonyl)amino]-8-azabicyclo[3.2.1]octan-8-yl]ethanesulfonic acid
CFAMM00213333 CHEMBL2087334 Bioactive N-[(1R,5S)-8-[2-hydroxy-3-(methanesulfonamido)propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213320 CHEMBL553405 Bioactive SureCN3981206
CFAMM00213299 CHEMBL553685 Bioactive N-[(1R,5S)-8-[5-(4-methylsulfonylpiperazin-1-yl)pentyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213326 CHEMBL549449 Bioactive N-[(1R,5S)-8-[3-(4-methylsulfonylpiperazin-1-yl)propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213339 CHEMBL555693 Bioactive N-[(1R,5S)-8-[7-(4-methylsulfonylpiperazin-1-yl)heptyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213306 CHEMBL556326 Bioactive N-[(1R,5S)-8-[8-(4-methylsulfonylpiperazin-1-yl)octyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213319 CHEMBL553404 Bioactive N-[(1R,5S)-8-[7-[methyl-[3-[methyl(methylsulfonyl)amino]propyl]amino]heptyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213332 CHEMBL2087335 Bioactive SureCN2098654
CFAMM00213312 CHEMBL559050 Bioactive N-[(1R,5S)-8-[3-[methyl-[3-[methyl(methylsulfonyl)amino]propyl]amino]propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213338 CHEMBL538635 Bioactive N-[(1R,5S)-8-[(2S)-2-hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00213301 DNC001417 Investigative Drug TD-5108

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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