CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID55
Family Name C-C chemokine receptor type 5 Ligand Tak-220 Family
No. of Seeds 8 No. of Other Members 56
Family Centroid CFAMM00176346 Functional Category Investigative Drug with Natural Product
Superfamily C-C chemokine receptor type 5 Ligand Tak-220 Superfamily
Class Class 1375

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 5 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand CH... 3 5
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Neuropeptide Y receptor type 2 ligand N-[3-chloro-4-[2-(cyclop... 1 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 7 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
C-C chemokine receptor type 5 ligand SureCN4768594 family 5 2
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-00CHN2 f... 3 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
C-C chemokine receptor type 5 ligand AC1MHYGF family 3 2
C-C chemokine receptor type 5 ligand AC1NQNH6 family 1 0
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3659568 family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 4
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Acetylcholinesterase inhibitor 1-(1-benzyl-3,4-dihydro-2H-quin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00176372 CHEMBL207485 Bioactive AC1NQNHC
CFAMM00176350 CHEMBL377026 Bioactive AC1NQNHL
CFAMM00176326 CHEMBL264832 Bioactive AC1NQNHF
CFAMM00176319 CHEMBL382252 Bioactive AGN-PC-00BT8V
CFAMM00176364 CHEMBL61117 Bioactive AGN-PC-00GBD5
CFAMM00176323 CHEMBL206088 Bioactive AGN-PC-00E93Z
CFAMM00176338 CHEMBL205706 Bioactive AC1NQNHI
CFAMM00176346 DPR000158 Investigative Drug Tak-220

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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