CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID556
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand H-dmt-tic-(2s,3s)-beta-mecha-phe-oh Family
No. of Seeds 20 No. of Other Members 35
Family Centroid CFAMM00213435 Functional Category Investigative Drug
Superfamily Mu-type opioid receptor and Delta-type opioid receptor Binder Superfamily
Class Class 1664

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Oxytocin receptor Ligand Oxytocin Family 30 182
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Plitidepsin family 15 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
Caspase-1 Inhibitor Yvad Family 1 0
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 5 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 2 1
Pol polyprotein inhibitor 168912-67-2 family 1 0
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Sigma non-opioid intracellular receptor 1 ligand N-(1-benzylpi... 1 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00213422 CHEMBL2369957 Bioactive (2S)-5-amino-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-5-oxopentanoic acid
CFAMM00213451 CHEMBL2369980 Bioactive (2R)-4-amino-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-4-oxobutanoic acid
CFAMM00213398 CHEMBL2369978 Bioactive (2R)-5-amino-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-5-oxopentanoic acid
CFAMM00213440 DNC013148 Investigative Drug H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-OH
CFAMM00213418 DNC013381 Investigative Drug H-Dmt-Tic-NH-CH2-CH2-NH2
CFAMM00213439 DNC013149 Investigative Drug H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-OH
CFAMM00213453 DNC013682 Investigative Drug H-Dmt-Tic-Asp-NH-Bzl
CFAMM00213438 DNC013147 Investigative Drug H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-OH
CFAMM00213435 DNC013140 Investigative Drug H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-OH
CFAMM00213444 DNC011945 Investigative Drug H-Tyr-D-Ala-Tic-Asp-Val-Val-Gly-NH2
CFAMM00213407 DNC014130 Investigative Drug H-Tyr-Tic-OH
CFAMM00213434 DNC013141 Investigative Drug H-Tyr-Tic-Cha-Phe-OH
CFAMM00213399 DNC012904 Investigative Drug H-Dmt-Tic-OH
CFAMM00213458 DNC014127 Investigative Drug H-2',6'-dimethyltyrosine-Tic-Phe-Phe-OH
CFAMM00213420 DNC013221 Investigative Drug H-Dmt-Tic-Glu-NH2
CFAMM00213433 DNC001450 Investigative Drug TIPP
CFAMM00213457 DNC014129 Investigative Drug H-2',6'-dimethyltyrosine-Tic-OH
CFAMM00213419 DNC013222 Investigative Drug H-Dmt-Tic-Glu-NH-(CH2)5-NH2
CFAMM00213432 DNC006840 Investigative Drug MCL-451

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22954 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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