CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID564
Family Name Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole Family
No. of Seeds 26 No. of Other Members 142
Family Centroid CFAMM00213601 Functional Category Investigative Drug with Natural Product
Superfamily Histamine H3 receptor Binder Superfamily
Class Class 1671

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mepyramine Family 5 65
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Renin Inhibitor Enalkiren Family 56 44
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Histamine H3 receptor Ligand Proxyfan Family 12 32
Nitric oxide synthase, inducible Inhibitor 4-(1h-imidazol-1-yl... 1 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Cytochrome P450 3A4 Inhibitor SK&F-96365 Family 2 26
Histamine H3 receptor Ligand 4-(2-(4-methoxyphenylamino)ethyl)... 3 1
Histamine H3 receptor Ligand Verongamine Family 1 0
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(2-phenoxy-eth... 1 10
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Substance-P receptor ligand (2S,3S)-3-[[3,5-bis(trifluoromethy... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Beta-1 adrenergic receptor ligand 1-[4-[2-(5-bromo-1H-imidazol... 3 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 14 2
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 1 2
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 2
Adenosine receptor A1 and Adenosine receptor A2b ligand 2-amin... 4 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 1
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 2 10
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Histamine H3 receptor ligand AGN-PC-075YUJ family 2 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 5
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(1,3-benzodi... 1 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Glutaminyl-peptide cyclotransferase inhibitor 1-(3,4-dimethoxy... 1 17
Alpha-2A adrenergic receptor and Alpha-1A adrenergic receptor ... 1 3
Alpha-1A adrenergic receptor ligand AGN-PC-0793UT family 3 3
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Putative NP ZINC32497112 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00213589 CHEMBL128495 Bioactive (Z)-but-2-enedioic acid;[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanol
CFAMM00213604 CHEMBL115091 Bioactive (NE)-N-[1-[4-[3-(1H-imidazol-5-yl)propoxy]-2-methylphenyl]ethylidene]hydroxylamine
CFAMM00213568 CHEMBL112681 Bioactive (Z)-but-2-enedioic acid;[(E)-1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]ethylideneamino]urea
CFAMM00213546 CHEMBL113181 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]pentylidene]hydroxylamine
CFAMM00213626 CHEMBL322481 Bioactive AGN-PC-074YI9
CFAMM00213645 CHEMBL112027 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]butan-1-ol
CFAMM00213580 CHEMBL112301 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]butylidene]hydroxylamine
CFAMM00213659 CHEMBL114085 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]ethylidene]hydroxylamine
CFAMM00213515 CHEMBL420124 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]propylidene]hydroxylamine
CFAMM00213531 CHEMBL200267 Bioactive 4-(1H-imidazol-5-ylmethyl)-1-(3-phenoxypropyl)piperidine
CFAMM00213523 CHEMBL112676 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]ethanol
CFAMM00213585 CHEMBL128385 Bioactive (Z)-but-2-enedioic acid;5-[3-(4-methoxyphenoxy)propyl]-1H-imidazole
CFAMM00213613 CHEMBL21230 Bioactive 5-[3-(4-iodophenoxy)propyl]-1H-imidazole
CFAMM00213549 CHEMBL326081 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methylidene]hydroxylamine
CFAMM00213500 CHEMBL324724 Bioactive (Z)-but-2-enedioic acid;N'-hydroxy-4-[3-(1H-imidazol-5-yl)propoxy]benzenecarboximidamide
CFAMM00213621 CHEMBL322039 Bioactive SureCN4385045
CFAMM00213535 CHEMBL123857 Bioactive SureCN7961162
CFAMM00213519 CHEMBL326624 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[1-[4-[3-(1H-imidazol-5-yl)propoxy]-3-methylphenyl]ethylidene]hydroxylamine
CFAMM00213561 CHEMBL132798 Bioactive SureCN4377932
CFAMM00213577 CHEMBL321835 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[1-[2-fluoro-4-[3-(1H-imidazol-5-yl)propoxy]phenyl]ethylidene]hydroxylamine
CFAMM00213505 CHEMBL440788 Bioactive 5-[3-(3-iodophenoxy)propyl]-1H-imidazole
CFAMM00213558 DNC012649 Investigative Drug 4-[3-(4-Ethynyl-phenoxy)-propyl]-1H-imidazole
CFAMM00213639 DNC001483 Investigative Drug UCL-1390
CFAMM00213623 DNC003698 Investigative Drug 4-[3-(4-Methoxy-phenoxy)-propyl]-1H-imidazole
CFAMM00213557 DNC012646 Investigative Drug 4-[3-(4-Butyl-phenoxy)-propyl]-1H-imidazole
CFAMM00213601 DNC003688 Investigative Drug 4-(3-Phenoxy-propyl)-1H-imidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543