CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID574
Family Name Tumor necrosis factor Inhibitor Y-39041 Family
No. of Seeds 9 No. of Other Members 51
Family Centroid CFAMM00213786 Functional Category Investigative Drug with Natural Product
Superfamily Cytochrome P450 3A4 and Tumor necrosis factor Binder Superfamily
Class Class 719

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
u-type opioid receptor ligand opiate opiate analog Oxymorphone... 22 105
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Eptazocine Hbr family 6 8
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
D(3) dopamine receptor Ligand U-99194A Family 7 33
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Cytochrome P450 3A4 Inhibitor 1,2-diacetoxylycorine Family 4 19
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Regulator of G-protein signaling 12 and Beta-lactamase inhibit... 1 7
D(3) dopamine receptor ligand S 14297 family 1 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melanin-concentrating hormone receptor 1 ligand 6-methoxy-4-[[... 2 15
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 0
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Mu-type opioid receptor ligand N-[2-[(2-amino-2-oxoethyl)-[2-(... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
C-C chemokine receptor type 5 ligand AC1NULA4 family 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00213756 CHEMBL10451 Bioactive 2-(1,3-benzodioxol-5-yl)-N-methyl-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)ethanamine
CFAMM00213761 CHEMBL10067 Bioactive 2-(1,3-benzodioxol-5-yl)-N-[(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-N-methylethanamine
CFAMM00213748 CHEMBL1822858 Bioactive 1-[3-[4-(1,3-benzodioxol-5-yl)phenoxy]propyl]piperidine
CFAMM00213780 DNC001531 Investigative Drug Zamifenacin
CFAMM00213786 DNC001521 Investigative Drug Y-39041

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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