CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID58
Family Name 72 kDa type IV collagenase Inhibitor Batimastat Family
No. of Seeds 6 No. of Other Members 52
Family Centroid CFAMM00176394 Functional Category Investigative Drug
Superfamily 72 kDa type IV collagenase Inhibitor Batimastat Superfamily
Class Class 1376

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Angiotensin-converting enzyme Inhibitor Temocapril Family 4 15
Cathepsin K Inhibitor Odanacatib Family 33 84
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Neprilysin Inhibitor Thiorphan Family 41 68
Neuromedin-K receptor Ligand Senktide Family 15 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 2 2
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 4 3
Substance-K receptor ligand N-[1-[[(2S)-5-[4-(dimethylsulfamoy... 9 16
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 4 2
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 1 1
Growth hormone secretagogue receptor type 1 ligand SureCN76469... 4 4
Sigma non-opioid intracellular receptor 1 ligand ST50280143 fa... 3 54
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
Vasopressin V1a receptor and Oxytocin receptor ligand (2S)-N-[... 5 4
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 9 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 6 6
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Growth hormone secretagogue receptor type 1 ligand (2S)-2,6-di... 2 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 0
Prothrombin and Cationic trypsin inhibitor (2S)-N-[[4-[(Z)-C-a... 6 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Pol polyprotein inhibitor AC1LA4ZN family 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Calpain-1 catalytic subunit and Cathepsin B inhibitor N-(4-ami... 1 0
Prothrombin inhibitor [(1R)-4-carbamimidoylsulfanyl-1-[[2-[met... 1 0
Carbonic anhydrase 2 inhibitor AGN-PC-07C00S family 4 1
5-hydroxytryptamine receptor 1A ligand (3R)-N-(1-adamantyl)-1,... 2 0
Peptide deformylase inhibitor N-[(2S)-1-[cyclopentylmethyl-[2-... 1 0
Lethal(3)malignant brain tumor-like protein 1 and Nuclear rece... 1 10
DNA-(apurinic or apyrimidinic site) lyase and Cytochrome P450 ... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor Su... 6 5
Histone deacetylase 6 inhibitor AGN-PC-0C7PT7 family 4 0
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00176403 CHEMBL419011 Bioactive (2S,3R)-N-hydroxy-3-(2-methylpropyl)-N'-[(2S)-1-oxo-3-phenyl-1-thiophen-2-ylpropan-2-yl]-2-prop-2-enylbutanediamide
CFAMM00176425 CHEMBL1080780 Bioactive (2S)-2-amino-N-[(1S)-1-cyano-2-phenylethyl]-3-thiophen-2-ylpropanamide
CFAMM00176385 CHEMBL114427 Bioactive GI 129471
CFAMM00176431 CHEMBL1080601 Bioactive (2S)-2-amino-N-[(1S)-1-cyano-2,2-diphenylethyl]-3-thiophen-2-ylpropanamide
CFAMM00176406 CHEMBL306912 Bioactive (2R)-N-[(2R)-3-(1-benzothiophen-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176394 DNC000274 Investigative Drug Batimastat

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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