CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID589
Family Name Voltage-dependent L-type calcium channel Ligand PD173212 Family
No. of Seeds 24 No. of Other Members 104
Family Centroid CFAMM00214105 Functional Category Investigative Drug with Natural Product
Superfamily Elagolix Superfamily
Class Class 1003

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Oxytocin receptor Ligand Oxytocin Family 30 182
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Elagolix family 43 98
Dapoxetine family 3 40
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Flovagatran family 12 546
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU85493 F... 1 0
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Integrin beta-3 Inhibitor FK-633 Family 2 12
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Plasmepsin-2 Inhibitor KNI-10079 Family 19 8
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 8 5
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Urotensin-2 receptor Ligand SB-436811 Family 6 71
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
D(2) dopamine receptor Ligand Epidepride Family 31 66
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Amine oxidase [flavin-containing] B Inhibitor (r)-n2-{4-[(3-ch... 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 2 3
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6... 11 8
Pol polyprotein inhibitor 180968-31-4 family 8 13
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Cathepsin S inhibitor SureCN6857538 family 2 12
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Histamine H3 receptor ligand SureCN4319687 family 8 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Caspase-1 inhibitor (3S)-5-(3,3-diphenylpropanoyloxy)-3-[[(2S)... 3 6
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Pol polyprotein inhibitor MK-944a family 6 1
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6367561 f... 20 12
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Neprilysin inhibitor SureCN389939 family 5 6
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Prostaglandin D2 receptor 2 ligand SureCN1713638 family 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 12 54
Pol polyprotein inhibitor (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-... 11 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Integrin beta-1 and Integrin alpha-4 inhibitor (4S)-4-[benzene... 7 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
NS3 inhibitor CHEMBL201121 family 1 4
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Pol polyprotein inhibitor L-689,502 family 17 2
Dipeptidyl peptidase 4 inhibitor 2-cyanopyrrolidine 21e family 6 7
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Motilin receptor ligand SureCN74051 family 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Macrophage metalloelastase inhibitor 2-(2,5-dichlorophenyl)sul... 1 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Renin inhibitor AGN-PC-076HPD family 1 0
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
C-C chemokine receptor type 3 and C-C chemokine receptor type ... 3 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Pol polyprotein inhibitor AC1NS2O6 family 3 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Histamine H3 receptor ligand SureCN7244264 family 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-4-o... 4 5
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Neutrophil collagenase and Collagenase 3 inhibitor [4-(4-chlor... 2 0
Pol polyprotein inhibitor AC1LALH8 family 2 1
Tryptase alpha/beta-1 and Tryptase delta inhibitor [4-[[2-[[4-... 2 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Calpain-2 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 2
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Scytalone dehydratase inhibitor AGN-PC-074L4J family 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Neuromedin-K receptor ligand SureCN2478117 family 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 1 0
Transient receptor potential M8 protein ligand 2-(2,3-dihydro-... 1 0
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 2 1
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 0
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Dipeptidyl peptidase 4 inhibitor 3-[[2-[(2S,4S)-2-cyano-4-fluo... 5 1
Sigma non-opioid intracellular receptor 1 ligand (1R,5S)-9-[(4... 3 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Oxysterols receptor LXR-alpha ligand Tertiary amine, 9 family 2 2
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 2 2
Dipeptidyl peptidase 4 inhibitor 7-[(3R)-3-amino-4-(2,4,5-trif... 2 0
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
NS3 inhibitor AC1NQTOZ family 2 0
Metabotropic glutamate receptor 1 ligand methyl (2R)-2-[[(1aR,... 2 0
Potassium voltage-gated channel subfamily A member 5 and Potas... 3 0
N-acylethanolamine-hydrolyzing acid amidase inhibitor (4-pheny... 1 0
Cytochrome P450 2C9 and Lethal factor inhibitor UPCMLD00WMAL3-... 5 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0
Pol polyprotein inhibitor AC1MHYEO family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN4877195 family 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 2 0
NP Molport-006-318-109 Family 13 0
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0
N'-[[4-(4-methoxyphenyl)oxan-4-yl]methyl]-N-[(1-phenylcyclopen... 1 1


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Functional Category

Molecule Name

CFAMM00214117 CHEMBL311418 Bioactive benzyl N-[(2S)-1-[[5-[benzyl(methyl)amino]-4,4-difluoro-3,5-dioxo-1-(4-phenylmethoxyphenyl)pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00214171 CHEMBL359686 Bioactive N-[2-[di(propan-2-yl)amino]ethyl]-2-[2-(3-methoxyphenyl)acetyl]-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1-carboxamide
CFAMM00214108 CHEMBL178216 Bioactive N-[2-[di(propan-2-yl)amino]ethyl]-2-(3-hydroxy-2-phenylpropanoyl)-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1-carboxamide
CFAMM00214124 CHEMBL360877 Bioactive N-[2-[di(propan-2-yl)amino]ethyl]-6-phenylmethoxy-2-(2-phenylpropanoyl)-3,4-dihydro-1H-isoquinoline-1-carboxamide
CFAMM00214164 CHEMBL123016 Bioactive MDL 73,669
CFAMM00214100 CHEMBL1161829 Bioactive 2-amino-2-methyl-N-[(2R)-1-oxo-5-phenyl-1-spiro[2H-1-benzofuran-3,4'-piperidine]-1'-ylpentan-2-yl]propanamide
CFAMM00214115 CHEMBL15705 Bioactive benzyl N-[(2S)-1-[[5-(benzylamino)-4,4-difluoro-3,5-dioxo-1-(4-phenylmethoxyphenyl)pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00214137 CHEMBL170805 Bioactive SureCN10630788
CFAMM00214178 CHEMBL77630 Bioactive (4-benzylphenyl)methyl-[2-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]-4-(4-methoxyphenyl)butyl]phosphinic acid
CFAMM00214121 CHEMBL19973 Bioactive benzyl N-[(2S)-1-[[4,4-difluoro-3,5-dioxo-1-(4-phenylmethoxyphenyl)-5-(propan-2-ylamino)pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00214190 CHEMBL264739 Bioactive benzyl N-[(2S)-1-[[4,4-difluoro-5-(2-methylpropylamino)-3,5-dioxo-1-(4-phenylmethoxyphenyl)pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00214218 CHEMBL129637 Bioactive N-[2-[di(propan-2-yl)amino]ethyl]-2-(3-oxo-2-phenylbutanoyl)-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1-carboxamide
CFAMM00214183 CHEMBL423222 Bioactive benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]amino]pentan-2-yl]carbamate
CFAMM00214135 CHEMBL283726 Bioactive benzyl N-[(2S)-1-[[4,4-difluoro-5-[[(1S)-1-methoxy-2-methylpropyl]amino]-3,5-dioxo-1-(4-phenylmethoxyphenyl)pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00214176 CHEMBL180992 Bioactive N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-phenylacetyl)-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1-carboxamide
CFAMM00214195 CHEMBL181832 Bioactive N-[2-[di(propan-2-yl)amino]ethyl]-2-[2-(2-methoxyphenyl)acetyl]-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1-carboxamide
CFAMM00214105 DNC001583 Investigative Drug PD173212

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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