CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID592
Family Name Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid Family
No. of Seeds 7 No. of Other Members 97
Family Centroid CFAMM00214337 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Glutamate carboxypeptidase 2 and Beta-lactamase Binder Superfamily
Class Class 1688

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family 22 503
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Solute carrier family 22 member 6 Inhibitor Probenecid Family 2 22
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
DNA topoisomerase 1 Inhibitor Beta-lapachone Family 3 66
Serine/threonine-protein kinase mTOR and K-RAS protein Inhibit... 2 20
Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family 4 13
Metabotropic glutamate receptor 1 Ligand 4-(1-amino-1-carboxy-... 3 5
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Inhibi... 2 119
Beta-lactamase Inhibitor 4-carboxyphenylboronic Acid Family 1 1
Carbonic anhydrase 2 Inhibitor Sodium 2,3,5,6-tetrafluorobenzo... 1 0
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Liver carboxylesterase 1 Inhibitor 2,2-dimethoxy-1,2-diphenyl-... 1 16
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carbamoylbenzyl)-5... 2 1
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Protein kinase C delta type and Protein kinase C alpha type In... 4 105
4-hydroxyphenylpyruvate dioxygenase Inhibitor 2-(2-iodo-benzoy... 3 1
Solute carrier family 52, riboflavin transporter, member 2 Inh... 1 7
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 19
Arachidonate 15-lipoxygenase inhibitor SureCN9469035 family 6 40
Thyrotropin receptor and Survival motor neuron protein ligand ... 1 17
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 1 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-[4-(2,4-di... 3 4
Prostaglandin E2 receptor EP2 subtype ligand 4-[2-[(1R,3R)-3-h... 1 6
Thyrotropin receptor and Retinal dehydrogenase 1 ligand NINHYD... 1 1
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Beta-lactamase inhibitor CHEMBL1358094 family 1 10
Kynurenine 3-monooxygenase inhibitor (Z)-4-(3-chlorophenyl)-4-... 3 0
Microtubule-associated protein tau and Putative fructose-1,6-b... 1 1
Benzyloxycarbonyls Metabolite Benzyl acetate Family 5 53
Indanes Metabolite (R)-Pterosin B Family 5 8
Aromatic Homomonocyclic Compounds Metabolite Dimethylbenzyl ca... 2 11
Benzyloxycarbonyls Metabolite Benzyl acetoacetate Family 1 6
[(1S,2S,5R)-2-hydroxy-2-methyl-5-prop-1-en-2-ylcyclohexyl] ben... 1 2
(1S)-1-hydroxy-1,4-dimethyl-2,3-dihydrocyclopenta[b]anthracene... 1 1
carboxylate NP ZINC04026424 Family 3 7
methylbenzoate NP 7-oxocyclohepta-1,3,5-trien-1-yl 3-methylben... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00214324 CHEMBL1374420 Bioactive TEREPHTHALIC ACID
CFAMM00214294 DNC011918 Investigative Drug 4-Iodyl-benzoic acid
CFAMM00214337 DNC003356 Investigative Drug 4-(Hydroxymercury)Benzoic Acid
CFAMM00214245 DNC014119 Investigative Drug 3-boronobenzoic acid
CFAMM00214313 DNC001619 Investigative Drug 4-MA
CFAMM00214291 DNC011910 Investigative Drug 3-Iodyl-benzoic acid
CFAMM00214297 DNC003337 Investigative Drug 1,3,5-BENZENETRICARBOXYLIC ACID

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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