CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID596
Family Name Histamine H3 receptor Ligand A-317920 Family
No. of Seeds 9 No. of Other Members 240
Family Centroid CFAMM00214616 Functional Category Investigative Drug with Natural Product
Superfamily Histamine H3 receptor Ligand A-317920 Superfamily
Class Class 1691

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Histone deacetylase Inhibitor Abexinostat Family 1 20
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Granulocyte colony-stimulating factor receptor Ligand N-(2-mor... 1 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Substance-K receptor ligand 5-chloro-N-[1-[[(2S)-5-[4-(oxan-4-... 2 4
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 4
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-074X... 5 6
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Kappa-type opioid receptor ligand 2-(1-benzofuran-4-yl)-N-meth... 4 5
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 14
Prelamin-A/C inhibitor CHEMBL1330545 family 1 18
Sodium/iodide cotransporter inhibitor (3-methoxyphenyl)methyl ... 4 12
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 35
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1424193 family 1 0
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 2 9
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(1-benzofuran-2-y... 3 1
Mu-type opioid receptor ligand SureCN9379472 family 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 2 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Histamine H3 receptor ligand SureCN2785131 family 7 1
Peptide deformylase inhibitor N-[(2R)-2-(cyclopentylmethyl)-3-... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Collagenase 3 and Matrix metalloproteinase-14 inhibitor AGN-PC... 10 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Lysosomal Pro-X carboxypeptidase inhibitor 1'-(1-benzofuran-2-... 1 0
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 1 0
Histamine H3 receptor ligand SureCN5221194 family 1 8
Histamine H3 receptor ligand SureCN5218144 family 4 6
Histamine H3 receptor ligand SureCN5216152 family 1 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 3 19
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 3 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 0
Collagenase 3 inhibitor 4-[4-[[5-(2-ethoxyethyl)-2,4,6-trioxo-... 5 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-methylfuran-3-... 2 1
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 4 13
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 5 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Histamine H3 receptor ligand SureCN7244264 family 1 0
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Collagenase 3 and Matrix metalloproteinase-14 inhibitor AGN-PC... 1 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 2 20
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Smoothened homolog inhibitor SureCN13591524 family 1 2
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Mitogen-activated protein kinase 14 and Heat shock protein bet... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 1
Protein kinase C theta type and Protein kinase C epsilon type ... 1 0
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1S)-1-carboxy... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Capsid scaffolding protein inhibitor AC1LAC52 family 1 0
Huntingtin and Ras-related protein Rab-9A inhibitor CHEMBL1971... 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00AWDS ... 1 0
Sterol O-acyltransferase 1 inhibitor AGN-PC-073SM7 family 1 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor (E)-... 4 0
Putative NP ZINC02099241 Family 12 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00214859 CHEMBL1084765 Bioactive N-[1-[[(2S)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzofuran-2-carboxamide
CFAMM00214598 CHEMBL424074 Bioactive AGN-PC-075L9H
CFAMM00214572 CHEMBL161479 Bioactive N-[(2R)-1-[4-[3-[4-(cyclopropanecarbonyl)-3-fluorophenoxy]propyl]piperazin-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00214757 CHEMBL153018 Bioactive N-[(2S)-1-[[(1R)-1-cyano-2-phenylmethoxyethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00214799 CHEMBL258031 Bioactive N-[(3R,5R)-1-azabicyclo[3.2.1]octan-3-yl]-1-benzofuran-5-carboxamide
CFAMM00214878 CHEMBL2036650 Bioactive 2-[4-(furan-2-carbonyl)piperazin-1-yl]-1-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]ethanone
CFAMM00214837 CHEMBL1083848 Bioactive 5-methyl-N-[1-[[(2S)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzofuran-2-carboxamide
CFAMM00214616 DNC002332 Investigative Drug A-317920

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24336 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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