CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID60
Family Name Lethal factor Inhibitor GM6001 Family
No. of Seeds 50 No. of Other Members 435
Family Centroid CFAMM00176462 Functional Category Investigative Drug with Natural Product
Superfamily Melanocortin receptor 3 and Melanocortin receptor 4 Binder Superfamily
Class Class 147

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Alpha adrenergic receptor ligand ergot alkaloid Dihydroergota... 7 12
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Epidermal Growth Factor family 111 209
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
HIV-1 protease Inhibitor Atazanavir Family 16 58
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Triprolidine Family 19 316
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
26S proteasome Inhibitor Bortezomib Family 7 65
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Prothrombin Inhibitor Ximelegatran Family 8 157
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
NS5A protein Inhibitor Bms 790052 Family 5 9
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
BIBT986 family 7 96
Amg 423 family 7 47
Setipiprant family 5 118
CBP-501 family 7 8
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
ABC294640 family 5 75
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
XL-888 family 16 85
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Sarcoplasmic/endoplasmic reticulum calcium ATPase Inhibitor Cy... 1 0
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
C-X-C chemokine receptor type 2 Ligand Sb 272844 Family 7 3
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibi... 2 5
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Adenosine receptor A3 and Potassium voltage-gated channel subf... 1 18
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 7 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Endothelin-converting enzyme 1 inhibitor 2-[[1-[[(2S)-4-methyl... 2 8
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 3 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 1
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Acetylcholinesterase inhibitor AGN-PC-07ZG1K family 3 0
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Caspase-1 inhibitor 5-[(7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]hep... 1 0
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Cathepsin K inhibitor SureCN2155973 family 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoy... 5 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 5 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 4
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Platelet-activating factor receptor ligand YM-461 family 1 11
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Coagulation factor X inhibitor SureCN4172349 family 7 3
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 1 0
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0
Histone deacetylase 4 and Histone deacetylase 3 inhibitor 4-az... 2 1
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 3 2
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Serine/threonine-protein kinase PLK1 and MAP kinase-activated ... 1 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Relaxin-3 receptor 1 and Relaxin-3 receptor 2 ligand CHEMBL203... 4 1
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Prothrombin inhibitor 1o0d family 2 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-(piperidin... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Coagulation factor X and Prothrombin inhibitor SureCN8237487 f... 16 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Motilin receptor ligand SureCN2768052 family 3 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 3 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 3 3
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
Somatostatin receptor type 5 ligand L-817,818 family 2 0
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2S)-2... 5 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... 2 0
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Growth factor receptor-bound protein 2 ligand 2-[4-[(2S)-3-[[1... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Gastrin/cholecystokinin type B receptor ligand (2R)-2-[[5-(8-a... 2 3
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0
Cyclin-dependent kinase 2 inhibitor SureCN6589205 family 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Chymase inhibitor SureCN408571 family 1 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Angiotensin-converting enzyme inhibitor AC1L1IZN family 2 2
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-(butylsulfo... 1 0
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Angiotensin-converting enzyme and Endothelin-converting enzyme... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Coagulation factor X inhibitor 3-chloroindole compound, 20 family 4 5
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Dipeptidyl peptidase 4 inhibitor SureCN5777667 family 1 4
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
P2X purinoceptor 7 inhibitor N'-quinolin-5-yladamantane-1-carb... 2 9
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
Histamine H3 receptor ligand SureCN3542210 family 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 2C ligand (5E)-5-[(5,6-dichloro-1... 1 0
Translocator protein inhibitor CHEMBL1672413 family 1 2
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Androgen receptor ligand CHEMBL181722 family 1 1
Substance-P receptor ligand methyl 6-acetamido-3-[[(2S)-1-[[3,... 1 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand CHE... 1 1
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN6080935 f... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 1 5
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 1 6
Neprilysin inhibitor AGN-PC-073PUZ family 1 0
Granzyme B inhibitor SureCN5917262 family 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9
Receptor-interacting serine/threonine-protein kinase 1 ligand ... 1 11
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor (2S)... 3 0
Cytochrome P450 2C9 and Cytochrome P450 3A4 inhibitor AGN-PC-0... 3 0
Insulin receptor ligand 2,5-dihydroxy-3-(1H-indol-3-yl)-6-phen... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
Coagulation factor X inhibitor (3R,4R)-3-N-[2-fluoro-4-(2-oxop... 1 0
Caspase-1 inhibitor (3S)-5-[2-(1H-indol-3-yl)acetyl]oxy-4-oxo-... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 2 0
Insulin-like growth factor 1 receptor ligand SureCN2940533 family 1 0
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Probable G-protein coupled receptor 142 ligand (2S)-2-[[(2R)-o... 1 0
Cytochrome P450 2C19 and Cytochrome P450 3A4 inhibitor (E)-3-[... 4 0
Prostaglandin D2 receptor 2 ligand AGN-PC-00QBAU family 1 24
Histone deacetylase 1 inhibitor N-[(2S)-1,8-dioxo-1-[2-(2-phen... 2 0
Reverse transcriptase/RNaseH inhibitor Thiazoloisoindol-5-one ... 1 1
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Cyclin-dependent kinase 2 inhibitor pyrrollylactam indolinone ... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]i... 11 0
12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]i... 16 0
(S)-2-amino-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4... 1 0
2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(1... 3 0
9H-pyrido[3,4-b]indole-3-carboxamide NP (1-(3-bromophenyl)-9h-... 5 0
6-(3-nitrophenyl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyri... 16 0
NP Agn-pc-099dao Family 2 0
8'-fluoro-6'-methyl-2,3,4,5',6',9-hexahydrodispiro[beta-carbol... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00176720 CHEMBL308429 Bioactive (2R)-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-N'-methoxy-2-(2-methylpropyl)butanediamide
CFAMM00176643 CHEMBL116972 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylsulfanylethylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176735 CHEMBL285418 Bioactive (2R)-N-[(2S)-1-(hexylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176763 CHEMBL2178731 Bioactive (2R,5S,8R)-5-benzyl-2-(1H-indol-3-ylmethyl)-3,6,10,14-tetraoxo-1,4,7,11-tetrazacyclotetradecane-8-carboxamide
CFAMM00176590 CHEMBL303892 Bioactive AGN-PC-074EX5
CFAMM00176488 CHEMBL68890 Bioactive (2R)-2-butyl-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]butanediamide
CFAMM00176921 CHEMBL70965 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(pyridin-2-ylmethylamino)propan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176596 CHEMBL2178733 Bioactive (2S)-2-[[(2R)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
CFAMM00176754 CHEMBL474704 Bioactive STK248816
CFAMM00176942 CHEMBL306224 Bioactive (2R)-N-[(2S)-1-(cyclopropylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176677 CHEMBL302368 Bioactive (2R)-N-[(2S)-1-(benzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176557 CHEMBL310249 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylmethylamino)propan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176979 CHEMBL70426 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176815 CHEMBL2371007 Bioactive 6-[(3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.4.0]hexadecan-9-yl]-N-hydroxyhexanamide
CFAMM00176746 CHEMBL71713 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(pentylamino)propan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176875 CHEMBL114665 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(2-methoxyethylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176632 CHEMBL306871 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-pyridin-2-ylethylamino)propan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176717 CHEMBL281795 Bioactive n4-hydroxy-2-isobutyl-n1-(9-oxo-1,8-diaza-tricyclo[10.6.1.013,18]nonadeca-12(19),13,15,17-tetraen-10-yl)-succinamide
CFAMM00176799 CHEMBL420932 Bioactive (2R)-N'-hydroxy-N-[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176814 CHEMBL71482 Bioactive (2R)-2-hexyl-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]butanediamide
CFAMM00176955 CHEMBL16180 Bioactive (1S,4R,8S,11S,14S,17S)-14-benzyl-17-(1H-indol-3-ylmethyl)-4-methyl-8-(2-methylpropyl)-2,6,9,12,15,18,22-heptazabicyclo[9.8.4]tricosane-3,7,10,13,16,19,21-heptone
CFAMM00176709 CHEMBL70417 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(pyridin-3-ylmethylamino)propan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176985 CHEMBL324140 Bioactive (2R)-N-[(2S)-1-[4-(dimethylamino)butylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176694 CHEMBL71071 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-[[(1S)-1-phenylethyl]amino]propan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176673 CHEMBL435324 Bioactive (2S,5S,8R)-5,8-dibenzyl-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetrone
CFAMM00176474 CHEMBL346285 Bioactive 2-[(2S,5R,8R,12R)-5,8-dibenzyl-2-(1H-indol-3-ylmethyl)-3,6,11,14-tetraoxo-1,4,7,10-tetrazacyclotetradec-12-yl]-N-[2-(dimethylamino)ethyl]acetamide
CFAMM00176776 CHEMBL56092 Bioactive SureCN13886970
CFAMM00176482 CHEMBL430704 Bioactive (2R)-N-[(2S)-1-[3-(dimethylamino)propylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176553 CHEMBL324023 Bioactive (2R)-N-[(2S)-1-[[4-[(dimethylamino)methyl]phenyl]methylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176944 CHEMBL306189 Bioactive (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-octylbutanediamide
CFAMM00176637 CHEMBL63317 Bioactive N-[1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-propan-2-ylpropanediamide
CFAMM00176764 CHEMBL72678 Bioactive (2R)-N'-hydroxy-N-[(2S)-1-(methylamino)-3-(1-methylindol-3-yl)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00176502 CHEMBL1793989 Bioactive (3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-(1H-indol-3-ylmethyl)-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone
CFAMM00176583 CHEMBL306470 Bioactive (2R)-N-[(2S)-1-(cyclopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00176462 DNC003010 Investigative Drug GM6001
CFAMM00176484 DNC000239 Investigative Drug Apicidin
CFAMM00176653 DNC004191 Investigative Drug N-(Ethylphosphoryl)-L-isoleucyl-L-Trp-NHCH3

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24041 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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