CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID601
Family Name 5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic receptor Ligand Ciproxifan Family
No. of Seeds 31 No. of Other Members 24
Family Centroid CFAMM00215067 Functional Category Investigative Drug with Natural Product
Superfamily Histamine H3 receptor and Alpha-2A adrenergic receptor Binder Superfamily
Class Class 1671

Cousin Family NamesSeedsMembers
Insulin receptor Ligand Insulin, Porcine Family 61 205
Renin Inhibitor Remikiren Family 100 126
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Eluxadoline family 4 85
Thromboxane-A synthase Inhibitor Dazoxiben Family 2 32
Renin Inhibitor Enalkiren Family 56 44
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
Histamine H3 receptor Ligand Proxyfan Family 12 32
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Aromatase Inhibitor 4'-cyano-3-(imidazolylmethyl)flavone Family 4 3
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Cytochrome P450 3A4 Inhibitor SK&F-96365 Family 2 26
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Histamine H3 receptor Ligand 4-(2-(4-methoxyphenylamino)ethyl)... 3 1
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Histamine H3 receptor Ligand Verongamine Family 1 0
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Falcipain-2B Inhibitor FITC-LMNNAEHINQFYMFI Family 3 5
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Beta-1 adrenergic receptor ligand 1-[4-[2-(5-bromo-1H-imidazol... 3 8
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 2 10
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Histamine H3 receptor ligand AGN-PC-075YUJ family 2 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 5
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(1,3-benzodi... 1 0
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Alpha-2A adrenergic receptor and Alpha-1A adrenergic receptor ... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Aromatase and Thromboxane-A synthase inhibitor tetrahydrobenzo... 1 0
Putative NP ZINC40310254 Family 74 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00215055 CHEMBL76440 Bioactive SureCN7991268
CFAMM00215048 CHEMBL128851 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]ethanone
CFAMM00215070 CHEMBL112099 Bioactive (Z)-but-2-enedioic acid;4-[3-(1H-imidazol-5-yl)propoxy]benzamide
CFAMM00215026 CHEMBL128513 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]-2-methylphenyl]ethanone
CFAMM00215040 CHEMBL129602 Bioactive (Z)-but-2-enedioic acid;1-[2-fluoro-4-[3-(1H-imidazol-5-yl)propoxy]phenyl]ethanone
CFAMM00215054 CHEMBL129317 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]-3-methylphenyl]ethanone
CFAMM00215076 CHEMBL477468 Bioactive (3S)-3-amino-4-(1H-imidazol-5-yl)-1-(4-phenoxyphenyl)butan-2-one;dihydrochloride
CFAMM00215033 CHEMBL129048 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]hexan-1-one
CFAMM00215069 CHEMBL309302 Bioactive AC1O4Y0N
CFAMM00215053 CHEMBL128380 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]propan-1-one
CFAMM00215032 CHEMBL340196 Bioactive SureCN4381007
CFAMM00215060 CHEMBL127404 Bioactive SureCN7971202
CFAMM00215068 CHEMBL127901 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]pentan-1-one
CFAMM00215045 CHEMBL113404 Bioactive (Z)-but-2-enedioic acid;4-[3-(1H-imidazol-5-yl)propoxy]benzohydrazide
CFAMM00215059 CHEMBL477469 Bioactive (3S)-3-amino-4-(1H-imidazol-5-yl)-1-(4-phenylmethoxyphenyl)butan-2-one;dihydrochloride
CFAMM00215037 CHEMBL420892 Bioactive SureCN7974811
CFAMM00215030 CHEMBL1795025 Bioactive (E)-but-2-enedioic acid;cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
CFAMM00215058 CHEMBL129146 Bioactive (Z)-but-2-enedioic acid;cyclopentyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
CFAMM00215066 CHEMBL131021 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-2-methylpropan-1-one
CFAMM00215050 CHEMBL116270 Bioactive (Z)-but-2-enedioic acid;(NE)-N-[cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methylidene]hydroxylamine
CFAMM00215064 CHEMBL340375 Bioactive AGN-PC-075K1X
CFAMM00215029 CHEMBL449398 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]heptan-1-one
CFAMM00215043 CHEMBL538333 Bioactive (3S)-3-amino-4-(1H-imidazol-5-yl)-1-(4-phenylmethoxyphenyl)butan-2-one;hydrochloride
CFAMM00215056 CHEMBL130989 Bioactive (Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]butan-1-one
CFAMM00215078 CHEMBL80348 Bioactive AC1O4Y0M
CFAMM00215027 CHEMBL128690 Bioactive (Z)-but-2-enedioic acid;cyclobutyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
CFAMM00215067 DNC002338 Investigative Drug Ciproxifan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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