CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name RAC-gamma serine/threonine-protein kinase Inhibitor GSK690693 Family
No. of Seeds 16 No. of Other Members 27
Family Centroid CFAMM00215160 Functional Category Investigative Drug
Superfamily RAC-gamma serine/threonine-protein kinase Inhibitor GSK690693 Superfamily
Class Class 1696

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2


External ID

Functional Category

Molecule Name

CFAMM00215153 CHEMBL494088 Bioactive SureCN3487696
CFAMM00215159 CHEMBL1794065 Bioactive GSK554170A
CFAMM00215165 CHEMBL521642 Bioactive 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
CFAMM00215144 CHEMBL493875 Bioactive 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]but-3-yn-1-ol
CFAMM00215151 CHEMBL1096291 Bioactive AGN-PC-07ZDZR
CFAMM00215143 CHEMBL493874 Bioactive SureCN13702486
CFAMM00215157 CHEMBL521823 Bioactive SureCN4715048
CFAMM00215163 CHEMBL522351 Bioactive (2S)-3-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-ynyl)imidazo[4,5-c]pyridin-7-yl]oxypropylamino]propane-1,2-diol
CFAMM00215142 CHEMBL523859 Bioactive 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-[(3S)-3-amino-4-phenylbutoxy]-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
CFAMM00215156 CHEMBL453510 Bioactive 4-[7-(2-aminoethoxy)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
CFAMM00215148 CHEMBL493269 Bioactive 4-[7-(4-aminobutoxy)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
CFAMM00215162 CHEMBL1794066 Bioactive GSK619487A
CFAMM00215155 CHEMBL494060 Bioactive SureCN3489566
CFAMM00215140 CHEMBL493911 Bioactive SureCN4063523
CFAMM00215154 CHEMBL523523 Bioactive 842148-40-7
CFAMM00215160 DNC002344 Investigative Drug GSK690693

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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