CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID609
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor PI-103 Family
No. of Seeds 7 No. of Other Members 37
Family Centroid CFAMM00215384 Functional Category Investigative Drug with Natural Product
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor PI-103 Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
MK-6096 family 3 69
Serine/threonine-protein kinase Chk1 Inhibitor N-(5,6-diphenyl... 9 100
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand SureCN6... 17 51
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor CHEM... 1 0
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
Vascular endothelial growth factor receptor 1 and Receptor-typ... 2 11
Prothrombin inhibitor SureCN6931925 family 3 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Vascular endothelial growth factor receptor 1 ligand CHEMBL197... 1 2
Hepatocyte growth factor receptor ligand 2-[2-amino-5-(1-piper... 4 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Activated CDC42 kinase 1 inhibitor 6-[4-(2-morpholin-4-ylethox... 7 1
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Histamine H3 receptor ligand 9-[2-(4-piperidin-1-ylpiperidin-1... 1 3
Glycogen synthase kinase-3 beta inhibitor N-[4-(4-amino-6-pyri... 1 0
Nonstructural protein 1 and Beta-lactamase inhibitor CHEMBL138... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00215389 CHEMBL538346 Bioactive 371935-79-4
CFAMM00215386 CHEMBL1667910 Bioactive SureCN4722261
CFAMM00215439 CHEMBL1830635 Bioactive CHEMBL1830635
CFAMM00215393 CHEMBL1828652 Bioactive CHEMBL1828652
CFAMM00215412 CHEMBL1830647 Bioactive CHEMBL1830647
CFAMM00215429 CHEMBL1830790 Bioactive CHEMBL1830790
CFAMM00215384 DNC002358 Investigative Drug PI-103

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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