CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID610
Family Name Histamine H3 receptor Ligand Proxyfan Family
No. of Seeds 12 No. of Other Members 32
Family Centroid CFAMM00215477 Functional Category Investigative Drug
Superfamily Histamine H3 receptor Binder Superfamily
Class Class 1671

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Histamine H3 receptor Ligand SCH79687 Family 11 29
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial Inhibitor Methyl 3-(1-benz... 3 12
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Histamine H3 receptor Ligand 4-(2-(4-methoxyphenylamino)ethyl)... 3 1
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Substance-P receptor ligand (2S,3S)-3-[[3,5-bis(trifluoromethy... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 1
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 3 20
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 2 2
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 2 10
Histamine H3 receptor ligand AGN-PC-075YUJ family 2 0
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 5
Histamine H3 receptor ligand AGN-PC-075YVW family 1 2
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Histamine H4 receptor and Histamine H3 receptor ligand AGN-PC-... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00215444 CHEMBL20295 Bioactive SureCN8119207
CFAMM00215450 CHEMBL494982 Bioactive AGN-PC-04S2ZZ
CFAMM00215449 CHEMBL20686 Bioactive 5-[3-[3-(4-iodophenyl)propoxy]propyl]-1H-imidazole
CFAMM00215479 CHEMBL1628574 Bioactive [125I]IODOPROXYFAN
CFAMM00215459 CHEMBL281187 Bioactive 5-[3-[(3-iodophenyl)methoxy]propyl]-1H-imidazole
CFAMM00215472 CHEMBL19172 Bioactive AC1O4XEW
CFAMM00215445 CHEMBL20211 Bioactive SureCN8141267
CFAMM00215471 CHEMBL495376 Bioactive AGN-PC-04S2ZN
CFAMM00215464 CHEMBL20328 Bioactive SureCN8119456
CFAMM00215478 DNC003690 Investigative Drug IODOPROXYFAN
CFAMM00215477 DNC002359 Investigative Drug Proxyfan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26841 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543