CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Histamine H3 receptor Ligand UCL1972 Family
No. of Seeds 3 No. of Other Members 23
Family Centroid CFAMM00215644 Functional Category Investigative Drug with Human Metabolite
Superfamily Histamine H3 receptor Ligand UCL1972 Superfamily
Class Class 1697

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Oxytocin receptor Ligand GSK221149 Family 1 26
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Carbonic anhydrase 2 Inhibitor 4-methoxyphenylsulfamide Family 2 27
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Sodium-dependent serotonin transporter and Acetylcholinesteras... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 2
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 3
NP (2r,3s,4r,5r,6s)-5-acetamido-2-(acetoxymethyl)-6-(3-nitroph... 5 3


External ID

Functional Category

Molecule Name

CFAMM00215643 CHEMBL132455 Bioactive N-[2-(4-nitrophenoxy)ethyl]-3-phenoxypropan-1-amine
CFAMM00215646 CHEMBL2029537 Bioactive (E)-3-fluoro-4-(4-nitrophenoxy)but-2-en-1-amine
CFAMM00215644 DNC002369 Investigative Drug UCL1972

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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