CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID64
Family Name Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(spiro[chromene-2,4'-piperidine]-4-yl)benzamide Family
No. of Seeds 17 No. of Other Members 381
Family Centroid CFAMM00177501 Functional Category Investigative Drug with Natural Product
Superfamily Cytochrome P450 2D6 and Delta-type opioid receptor Binder Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Zucapsacin family 7 177
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Histone deacetylase 1 Inhibitor N-hydroxy-8-(2-methoxyphenyl)-... 2 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 14
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 10
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 3 7
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
B1 bradykinin receptor ligand 4-(5-chloro-4-oxochromen-3-yl)-N... 1 5
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 3 15
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Potassium voltage-gated channel subfamily H member 2 and C-C c... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
C-C chemokine receptor type 3 and C-C chemokine receptor type ... 3 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Pol polyprotein inhibitor AC1LALH8 family 2 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 16 2
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Sodium/hydrogen exchanger 1 inhibitor 4-(1-acetylpiperidin-4-y... 1 1
Histone deacetylase 3 and Histone deacetylase 6 inhibitor (E)-... 1 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Breast cancer type 1 susceptibility protein and Huntingtin inh... 1 7
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 2 0
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC20762875 Family 7 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00177528 CHEMBL557121 Bioactive SureCN467150
CFAMM00177406 CHEMBL494462 Bioactive SureCN467302
CFAMM00177288 CHEMBL562478 Bioactive SureCN471412
CFAMM00177455 CHEMBL551615 Bioactive SureCN471406
CFAMM00177513 CHEMBL561339 Bioactive SureCN471356
CFAMM00177302 CHEMBL557257 Bioactive SureCN471405
CFAMM00177329 CHEMBL561882 Bioactive SureCN10259045
CFAMM00177447 CHEMBL562873 Bioactive SureCN471585
CFAMM00177579 CHEMBL495094 Bioactive SureCN471246
CFAMM00177335 CHEMBL494480 Bioactive SureCN467481
CFAMM00177409 CHEMBL557458 Bioactive SureCN467434
CFAMM00177348 CHEMBL494479 Bioactive SureCN471293
CFAMM00177431 CHEMBL561805 Bioactive AGN-PC-073XHK
CFAMM00177283 CHEMBL551412 Bioactive SureCN2072005
CFAMM00177214 CHEMBL556648 Bioactive SureCN10258955
CFAMM00177501 DNC009857 Investigative Drug 4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide
CFAMM00177251 DND000037 Investigative Drug ADL-5859

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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