CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID642
Family Name Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamide Family
No. of Seeds 18 No. of Other Members 168
Family Centroid CFAMM00216247 Functional Category Investigative Drug with Natural Product
Superfamily Acetylcholinesterase Inhibitor Ambenonium Superfamily
Class Class 496

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
DNA Binder Procarbazine Family 8 358
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Voltage-gated sodium channel Ligand Lacosamide Family 1 10
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Prothrombin Inhibitor LB30812 Family 12 36
Prothrombin Inhibitor Ppack Family 5 4
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 5 9
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 1 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(2... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 2 0
Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]... 5 11
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S,5S)-4-(1,3-dih... 3 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 10 18
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 6
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-(... 1 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Prothrombin inhibitor SureCN6921523 family 4 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 1 4
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[(2,5-di... 3 2
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 4 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 3 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 4 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
P2X purinoceptor 7 inhibitor (3S)-N-[[2-chloro-3-(trifluoromet... 1 6
B1 bradykinin receptor ligand N-[(1R)-1-[4-(3-chloro-2-propano... 1 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Mu-type opioid receptor ligand CHEMBL303404 family 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Gonadotropin-releasing hormone receptor ligand CHEMBL410779 fa... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Growth hormone secretagogue receptor type 1 ligand [(3R)-3-ami... 2 5
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Prothrombin inhibitor 1-(2-amino-3,3-diphenylpropanoyl)-N-[(3-... 1 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 2 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
P2X purinoceptor 7 inhibitor SureCN2574353 family 1 1
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN14523901 family 7 1
Beta-lactamase inhibitor CHEMBL1317875 family 1 5
Prelamin-A/C inhibitor CHEMBL1353052 family 1 1
Voltage-dependent T-type calcium channel subunit alpha-1H and ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00216355 CHEMBL317949 Bioactive (2S)-2-amino-4-[(3-chlorophenyl)methylamino]-1-piperidin-1-ylbutan-1-one
CFAMM00216231 CHEMBL1092167 Bioactive (2S)-N-[[4-(3,5-dichlorophenyl)phenyl]methyl]pyrrolidine-2-carboxamide
CFAMM00216294 CHEMBL330560 Bioactive (2S)-1-[(2S)-2-cyclohexyl-2-[[2-(diethylamino)-2-oxoethyl]amino]acetyl]-N-[(2,5-dichlorophenyl)methyl]pyrrolidine-2-carboxamide
CFAMM00216244 CHEMBL1957017 Bioactive (3S,6S,7R,9aS)-N-benzhydryl-7-[2-[(3-chlorophenyl)methylamino]ethyl]-6-[[(2S)-2-(methylamino)butanoyl]amino]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepine-3-carboxamide
CFAMM00216257 CHEMBL6736 Bioactive AGN-PC-074WVW
CFAMM00216286 CHEMBL117098 Bioactive SureCN6920896
CFAMM00216353 CHEMBL1097828 Bioactive (2R)-N-(2-adamantyl)-1-[(4-chlorophenyl)methyl]pyrrolidine-2-carboxamide
CFAMM00216196 CHEMBL103581 Bioactive 1-(2-AMINO-3,3-DIPHENYL-PROPIONYL)-PYRROLIDINE-3-CARBOXYLIC ACID 2,5-DICHLORO-BENZYLAMIDE
CFAMM00216248 CHEMBL42495 Bioactive (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-[(2,5-dichlorophenyl)methyl]pyrrolidine-2-carboxamide
CFAMM00216188 CHEMBL108183 Bioactive (2S)-1-(2-amino-3,3-diphenylpropanoyl)-N-[(2,5-dichlorophenyl)methyl]pyrrolidine-2-carboxamide
CFAMM00216291 CHEMBL441468 Bioactive (2S)-1-[(2R)-2-cyclohexyl-2-[[2-(diethylamino)-2-oxoethyl]amino]acetyl]-N-[(2,5-dichlorophenyl)methyl]pyrrolidine-2-carboxamide
CFAMM00216208 CHEMBL2218314 Bioactive SureCN2575876
CFAMM00216240 CHEMBL94640 Bioactive (2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-N-[(2,5-dichlorophenyl)methyl]pyrrolidine-2-carboxamide
CFAMM00216207 CHEMBL2218315 Bioactive SureCN2575688
CFAMM00216329 CHEMBL2218296 Bioactive SureCN3287064
CFAMM00216272 CHEMBL1222820 Bioactive (2S)-N-[(2,4-dichlorophenyl)methyl]-1-ethyl-5-oxopyrrolidine-2-carboxamide
CFAMM00216247 DNC002463 Investigative Drug D-leucyl-N-(3-chlorobenzyl)-L-prolinamide
CFAMM00216246 DNC002464 Investigative Drug D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27260 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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