CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID645
Family Name Macrophage migration inhibitory factor and Prothrombin Inhibitor 3-(4-hydroxy-phenyl)pyruvic Acid Family
No. of Seeds 2 No. of Other Members 49
Family Centroid CFAMM00216486 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Prothrombin and Estrogen receptor beta Binder Superfamily
Class Class 121

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand L-Tyrosine derivative Methyld... 2 3
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand Dienestrol Family 35 440
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Danthron family 11 141
taste receptor Ligand Cynarin Family 6 124
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Endothelin-1 receptor Ligand PD156707 Family 41 211
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benz... 2 6
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tyrosine-protein phosphatase non-receptor type 1 Ligand Phelli... 1 1
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor P-coum... 1 1
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Isocitrate lyase Inhibitor Bis(3-bromo-4,5-dihydroxyphenyl)met... 1 2
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
Prelamin-A/C inhibitor CHEMBL1495780 family 1 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Integrase inhibitor AC1O6FK1 family 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Catechol O-methyltransferase inhibitor 4,5-dihydroxybenzene-1,... 1 1
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Benzyl Alcohols and Derivatives Metabolite (2R,3S)-Piscidic ac... 1 1
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Phenols and Derivatives Metabolite 6-Gingesulfonic acid Family 1 2
1-(3,5-dihydroxyphenyl)-12-hydroxytridecan-2-one NP ZINC311562... 2 0
Putative NP ZINC49600254 Family 8 2
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00216486 DNC002476 Investigative Drug 3-(4-HYDROXY-PHENYL)PYRUVIC ACID
CFAMM00216547 DNC002742 Investigative Drug 2-(3,4-Dihydroxyphenyl)Acetic Acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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