CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID667
Family Name Oestrogen receptor and Tyrosine-protein phosphatase non-receptor type 1 Ligand Compound 15 Family
No. of Seeds 92 No. of Other Members 21
Family Centroid CFAMM00216793 Functional Category Investigative Drug
Superfamily Oestrogen receptor and Tyrosine-protein phosphatase non-receptor type 1 Ligand Compound 15 Superfamily
Class Class 1733

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand Raloxifene Family 4 169
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Acolbifene family 10 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 3 0
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Estrogen receptor and Estrogen receptor beta ligand (2S,3R)-2-... 5 0
Estrogen receptor and Estrogen receptor beta ligand (2S,3R)-2-... 3 0
Estrogen receptor and Estrogen receptor beta ligand SureCN7103... 1 1
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Prothrombin inhibitor SureCN6594996 family 7 8
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 8 0
Prothrombin inhibitor SureCN6594826 family 4 4
Estrogen receptor and Estrogen receptor beta ligand SureCN3115... 9 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 7 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN8476... 2 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 8 0
Estrogen receptor and Estrogen receptor beta ligand (2R,3S)-5-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00216824 CHEMBL431611 Bioactive (2S,3R)-3-cyclopentyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216851 CHEMBL329892 Bioactive (2S,3R)-5-fluoro-3-(4-hydroxyphenyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216790 CHEMBL362623 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216804 CHEMBL185480 Bioactive (2S,3R)-2-[4-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216864 CHEMBL367350 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2S)-2-pyrrolidin-1-ylbutoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216830 CHEMBL182887 Bioactive (2S,3R)-2-[4-[2-(3,3-dimethylpyrrolidin-1-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216843 CHEMBL183584 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216857 CHEMBL85881 Bioactive (2S,3R)-3-(cyclohexylmethyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216797 CHEMBL124474 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-(3-piperidin-1-ylpropyl)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216810 CHEMBL184360 Bioactive (2S,3R)-2-[4-[2-(9-azabicyclo[3.3.1]nonan-9-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216823 CHEMBL183263 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2S)-3-methyl-2-pyrrolidin-1-ylbutoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216870 CHEMBL327471 Bioactive (2R,3S)-3-(4-hydroxyphenyl)-8-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216849 CHEMBL122237 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-(2-piperidin-1-ylethoxymethyl)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216803 CHEMBL226268 Bioactive Desmethylarzoxifene (DMA)
CFAMM00216816 CHEMBL183489 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216796 CHEMBL122208 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-(3-piperidin-1-ylpropyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216842 CHEMBL328716 Bioactive (2R,3S)-5-fluoro-3-(4-hydroxyphenyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216856 CHEMBL91758 Bioactive (2R,3S)-3-(2-hydroxyphenyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216869 CHEMBL537254 Bioactive SureCN3807019
CFAMM00216809 CHEMBL367574 Bioactive (2S,3R)-2-[4-[2-[(3R,4S)-3,4-dimethylpyrrolidin-1-yl]ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216822 CHEMBL181944 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2S)-1-pyrrolidin-1-ylpropan-2-yl]oxyphenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216848 CHEMBL92027 Bioactive (2S,3R)-3-(3-hydroxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216862 CHEMBL185231 Bioactive (2S,3R)-2-[4-[2-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216788 CHEMBL90794 Bioactive (2S,3R)-2-[4-[2-(2,6-dimethylpiperidin-1-yl)ethoxy]phenyl]-3-(3-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216802 CHEMBL183092 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2S)-1-pyrrolidin-1-ylbutan-2-yl]oxyphenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216828 CHEMBL361056 Bioactive (2S,3R)-2-[4-[2-(3-azabicyclo[2.2.2]octan-3-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216841 CHEMBL418327 Bioactive AGN-PC-005GYU
CFAMM00216868 CHEMBL183344 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[2-[(2S)-2-methylpyrrolidin-1-yl]ethoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216808 CHEMBL180792 Bioactive (2S,3R)-3-(4-HYDROXYPHENYL)-2-(4-{[(2R)-2-PYRROLIDIN-1-YLPROPYL]OXY}PHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL
CFAMM00216821 CHEMBL316132 Bioactive (2S,3R)-3-cycloheptyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216787 CHEMBL85090 Bioactive (2S,3R)-3-cyclohexyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216801 CHEMBL183090 Bioactive SureCN2938899
CFAMM00216814 CHEMBL361751 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216840 CHEMBL182690 Bioactive SureCN2936260
CFAMM00216854 CHEMBL185383 Bioactive (2S,3R)-2-[4-[2-(1,1-dioxo-1,4-thiazinan-4-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216867 CHEMBL68940 Bioactive 4-[(2R,3S)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-3-yl]phenol
CFAMM00216807 CHEMBL185083 Bioactive (2S,3R)-2-[4-[2-(2-azaspiro[3.3]heptan-2-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216820 CHEMBL427324 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[2-[(3R)-3-propan-2-ylpyrrolidin-1-yl]ethoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216833 CHEMBL94225 Bioactive (2S,3R)-2-[4-[2-(cycloheptylamino)ethoxy]phenyl]-3-(3-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216846 CHEMBL179852 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-(2-methyl-2-pyrrolidin-1-ylpropoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216860 CHEMBL434525 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216800 CHEMBL184371 Bioactive CHEMBL184371
CFAMM00216813 CHEMBL184202 Bioactive (2S,3R)-2-[4-[2-(3-azabicyclo[3.1.0]hexan-3-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216826 CHEMBL361601 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[2-[(3S)-3-propan-2-ylpyrrolidin-1-yl]ethoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216866 CHEMBL362718 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-(2-thiomorpholin-4-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216853 CHEMBL315271 Bioactive (2S,3R)-3-(cyclopentylmethyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216832 CHEMBL365484 Bioactive (2S,3R)-2-[4-[2-[4-(2-hydroxyethyl)piperidin-1-yl]ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216806 CHEMBL369545 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2R)-2-pyrrolidin-1-ylbutoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216819 CHEMBL329902 Bioactive (2S,3R)-2-[4-[2-(dimethylamino)ethoxy]phenyl]-3-(3-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216859 CHEMBL183049 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216799 CHEMBL2113027 Bioactive (2S,3R)-2-[4-[2-[(3S)-3-ethylpyrrolidin-1-yl]ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216812 CHEMBL183086 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2R)-1-pyrrolidin-1-ylbutan-2-yl]oxyphenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216825 CHEMBL93546 Bioactive AGN-PC-0D9C68
CFAMM00216791 CHEMBL182794 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2R)-3-methyl-2-pyrrolidin-1-ylbutoxy]phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216805 CHEMBL182980 Bioactive (2S,3R)-2-(4-{2-[(3R,4R)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL
CFAMM00216852 CHEMBL184491 Bioactive 1-[2-[4-[(2S,3R)-6-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-2-yl]phenoxy]ethyl]piperidine-4-carboxamide
CFAMM00216831 CHEMBL183388 Bioactive (2S,3R)-2-[4-[2-[(3R)-3-ethylpyrrolidin-1-yl]ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216858 CHEMBL183044 Bioactive (2S,3R)-3-(4-hydroxyphenyl)-2-[4-[(2R)-1-pyrrolidin-1-ylpropan-2-yl]oxyphenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216811 CHEMBL183371 Bioactive (2S,3R)-2-[4-[2-(2,2-dimethylpyrrolidin-1-yl)ethoxy]phenyl]-3-(4-hydroxyphenyl)-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216871 CHEMBL85650 Bioactive (2S,3R)-3-(2-methylpropyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol
CFAMM00216794 DNC002512 Investigative Drug Compound 19
CFAMM00216793 DNC002511 Investigative Drug Compound 15
CFAMM00216792 DNC002515 Investigative Drug Compound 4-D

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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