CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name PF-4136309 family
No. of Seeds 16 No. of Other Members 27
Family Centroid CFAMM00178319 Functional Category Investigative Drug
Superfamily PF-4136309 Superfamily
Class Class 1382

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Melanocortin receptor 4 and Potassium voltage-gated channel su... 2 12
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 1
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 4 7
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
C-C chemokine receptor type 2 ligand N-[2-[[(3R)-1-(4-hydroxy-... 4 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Androgen receptor ligand 6-[(2S,3S)-1-(3-chloro-4-cyanophenyl)... 2 0


External ID

Functional Category

Molecule Name

CFAMM00178313 CHEMBL2029568 Bioactive [(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-[1-[4-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methanone
CFAMM00178338 CHEMBL2029570 Bioactive [(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-[1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]methanone
CFAMM00178312 CHEMBL2029420 Bioactive N-[2-[(3S)-3-[[4-hydroxy-4-(5-pyrimidin-5-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178325 CHEMBL1951772 Bioactive N-[2-[[(3R)-1-(4-hydroxy-4-pyrimidin-4-ylcyclohexyl)pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178311 CHEMBL2029421 Bioactive N-[2-[(3S)-3-[[4-hydroxy-4-(5-pyrazin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178324 CHEMBL1951771 Bioactive N-[2-[[(3R)-1-(4-hydroxy-4-pyrimidin-2-ylcyclohexyl)pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178336 CHEMBL2029419 Bioactive N-[2-[(3S)-3-[[4-hydroxy-4-(5-pyridin-4-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178309 CHEMBL1951768 Bioactive N-[2-[[(3R)-1-(4-hydroxy-4-pyridin-2-ylcyclohexyl)pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178323 CHEMBL1951770 Bioactive N-[2-[[(3R)-1-(4-hydroxy-4-pyridin-4-ylcyclohexyl)pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178316 CHEMBL2029567 Bioactive [(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-[1-[6-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methanone
CFAMM00178335 CHEMBL2029418 Bioactive N-[2-[(3S)-3-[[4-hydroxy-4-(5-pyridin-3-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178315 CHEMBL2029566 Bioactive [(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-[1-[3-(trifluoromethyl)phenyl]piperidin-4-yl]methanone
CFAMM00178332 CHEMBL2029417 Bioactive N-[2-[(3S)-3-[[4-hydroxy-4-(5-methylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00178340 CHEMBL2029572 Bioactive [(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-[4-hydroxy-1-[4-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methanone
CFAMM00178314 CHEMBL2029569 Bioactive [(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-[1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl]methanone
CFAMM00178319 DND000092 Investigative Drug PF-4136309

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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